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  2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Resolvin D1

Resolvin D1  (Synonyms: RvD1)

目錄號(hào): HY-125527 純度: ≥99.0%
COA 產(chǎn)品使用指南

Resolvin D1 (RvD1) 是炎癥的一種內(nèi)源性促分解介質(zhì)，衍生自在急性炎癥的緩解階段的 omega-3二十二碳六烯酸。Resolvin D1 通過調(diào)節(jié)肌動(dòng)蛋白聚合來阻止促炎性中性粒細(xì)胞遷移，減少巨噬細(xì)胞中 TNF-α 介導(dǎo)的炎癥，并增強(qiáng)巨噬細(xì)胞對(duì)凋亡細(xì)胞的吞噬作用。

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Resolvin D1 Chemical Structure

Resolvin D1 Chemical Structure

CAS No. : 872993-05-0

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規(guī)格 價(jià)格 是否有貨 數(shù)量
25 μg (265.6 μM * 250 μL in Ethanol) ￥8500
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Other Forms of Resolvin D1:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

體外研究
(In Vitro)

Resolvin D1 (RvD1) (1-100 nM；15 分鐘) 在原代人巨噬細(xì)胞中誘導(dǎo)劑量依賴性短期功能變化。RvD1 觸發(fā)細(xì)胞內(nèi) Ca2+ 釋放，阻斷趨化性遷移，并刺激微生物顆粒的吞噬作用，在 10 nM時(shí)效率最高[1]。
Resolvin D1 (0-500 nM；72 小時(shí)) 在 RAW264.7 巨噬細(xì)胞中顯示出不同濃度的 RvD1 對(duì) LPS 誘導(dǎo)的 TRAP 和組織蛋白酶 K 表達(dá)的強(qiáng)烈抑制作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Resolvin D1 (RvD1) (100-1000 ng；腹腔注射；第 10 天每天) 改善關(guān)節(jié)炎小鼠的 RA (類風(fēng)濕性關(guān)節(jié)炎) 臨床終點(diǎn)[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 18-20?g thirty 8-week-old female DBA/1J mice (collagen antibody-induced arthritis (CAIA))[3]
Dosage: 100, 500, and 1000?ng (or 1000 ng, daily on days 4-10)
Administration: i.p. injection; daily on days 10
Result: Exhibit a reduced arthritic score.
分子量

376.49

Formula

C22H32O5
CAS 號(hào)
性狀

液體

顏色

Colorless to light yellow

結(jié)構(gòu)分類
初始來源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

Solution, -20°C, 2 years
純度 & 產(chǎn)品資料

純度: 99.60%

參考文獻(xiàn)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Resolvin D1
目錄號(hào)：
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