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  1. Protein Tyrosine Kinase/RTK
  2. TAM Receptor
  3. RU-302

RU-302 是一種非選擇性的TAM 抑制劑,阻斷 TAM Ig1 胞外域和 Gas6 Lg 結(jié)構(gòu)域之間的界面。RU-302 用低微摩爾 IC50 有效阻斷 Gas6 誘導(dǎo)的 Axl 受體活化,并有效抑制肺癌腫瘤的生長。

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RU-302 Chemical Structure

RU-302 Chemical Structure

CAS No. : 1182129-77-6

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查看 TAM Receptor 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

RU-302 is a pan TAM inhibitor that blocks the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks Gas6-inducible Axl receptor activation with a low micromolar IC50in cell assays, and suppresses lung cancer tumor growth[1].

IC50 & Target

Axl

 

分子量

475.53

Formula

C24H24F3N3O2S

CAS 號
性狀

固體

顏色

White to off-white

運輸條件

Room temperature in continental US; may vary elsewhere.

儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
純度 & 產(chǎn)品資料
參考文獻
  • 摩爾計算器

  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Inquiry Information

產(chǎn)品名稱:
RU-302
目錄號:
HY-124066
需求量: