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  2. GPCR/G Protein
  3. CRFR
  4. DMP 696

DMP 696 是一種促腎上腺素皮質(zhì)激素釋放激素受體1 (CRHR1) 拮抗劑，常用于焦慮和抑郁癥的研究。

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DMP 696 Chemical Structure

DMP 696 Chemical Structure

CAS No. : 202578-52-7

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥4950
In-stock
1 mg ￥1750
In-stock
5 mg ￥4500
In-stock
10 mg 現(xiàn)貨 詢價
50 mg   詢價  
100 mg   詢價  

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MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻(xiàn)

查看 CRFR 亞型特異性產(chǎn)品:

  • 生物活性

  • 實(shí)驗參考方法

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

DMP 696 is a selective corticotropin-releasing hormone receptor 1 (CRHR1) antagonist, used for the treatment of anxiety and depression.

體內(nèi)研究
(In Vivo)

DMP696 (3?mg/kg, p.o.) attenuates consolidation of remote fear memories of mice, without affecting their expression and retention. WT mice treated with DMP696 for 1 week starting 24?h after foot shock also show reduced synaptosomal GluR1 levels than do shocked vehicle-treated controls[1]. Rats treated with different doses of DMP696 (1, 3, 10, 30 mg/kg) show very little freezing during the 2-minute preshock interval. Rats treated with DMP696 exhibit a significant overall reduction in CREB phosphorylation, in both the LA, and BLA, but not in the CeA. DMP696 treatment reduces levels of LA and BLA pCREB across all time intervals that do not differ significantly from homecage pCREB levels (P>0.05). In the CeA, both vehicle- and DMP696-treated rats exhibit significantly higher pCREB expression at each post-conditioning time interval than homecage pCREB levels. Rats in the 30 ng DMP696 group exhibit significantly less freezing in comparison to vehicle-treated animals[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

410.30

Formula

C18H21Cl2N5O2
CAS 號
性狀

固體

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗： 

DMSO 中的溶解度 : 100 mg/mL (243.72 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.4372 mL 12.1862 mL 24.3724 mL
5 mM 0.4874 mL 2.4372 mL 4.8745 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實(shí)驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實(shí)驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料
參考文獻(xiàn)
Animal Administration
[1]

DMP696 is dissolved in saccharose-flavored NaCl 0.9% containing 10% DMSO, 10% PEG 400, and Tween-80 (1 drop/mL). Drug suspension is delivered on an oat flake and then fed to animals at a final dose of 3?mg/kg. Controls receive an oat flake soaked with saccharose-flavored vehicle only. The dose of 3?mg/kg is chosen on the basis of pilot experiments in which doses of 3, 10, and 30?mg/kg have been compared. The drug solutions are always freshly pipetted onto the flake and shortly dried before delivery. Ad libitum-fed mice receive some saccharose-flavored oat flakes 2 days before starting an experiment to habituate them to the novel food. Over the course of treatment, mice show no signs of aversion against the drug-soaked flakes, but readily ate them within a few seconds after delivery.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
參考文獻(xiàn)

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4372 mL 12.1862 mL 24.3724 mL 60.9310 mL
5 mM 0.4874 mL 2.4372 mL 4.8745 mL 12.1862 mL
10 mM 0.2437 mL 1.2186 mL 2.4372 mL 6.0931 mL
15 mM 0.1625 mL 0.8124 mL 1.6248 mL 4.0621 mL
20 mM 0.1219 mL 0.6093 mL 1.2186 mL 3.0466 mL
25 mM 0.0975 mL 0.4874 mL 0.9749 mL 2.4372 mL
30 mM 0.0812 mL 0.4062 mL 0.8124 mL 2.0310 mL
40 mM 0.0609 mL 0.3047 mL 0.6093 mL 1.5233 mL
50 mM 0.0487 mL 0.2437 mL 0.4874 mL 1.2186 mL
60 mM 0.0406 mL 0.2031 mL 0.4062 mL 1.0155 mL
80 mM 0.0305 mL 0.1523 mL 0.3047 mL 0.7616 mL
100 mM 0.0244 mL 0.1219 mL 0.2437 mL 0.6093 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
DMP 696
目錄號：
HY-12131
需求量：