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  2. Anti-infection
  3. Bacterial Fungal Influenza Virus Antibiotic
  4. Tyrothricin

Tyrothricin  (Synonyms: 酪絲菌素)

目錄號: HY-120435 純度: 96.4%
COA 產品使用指南

Tyrothricin 是一種從短小芽孢桿菌中分離的多肽抗生素混合物，由酪氨酸和短桿菌肽組成。Tyrothricin 可抑制細菌，真菌和某些病毒的活性。含 Tyrothricin 的制劑可用于治愈咽喉痛或淺表及小面積傷口的感染。

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Tyrothricin Chemical Structure

Tyrothricin Chemical Structure

CAS No. : 1404-88-2

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規(guī)格 價格 是否有貨 數量
1 mg ￥560
In-stock
5 mg ￥1320
In-stock
10 mg ￥2240
In-stock
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100 mg   詢價  

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Other Forms of Tyrothricin:

  • 生物活性

  • 純度 & 產品資料

  • 參考文獻

生物活性

Tyrothricin is a polypeptide antibiotic mixture isolated from Bacillus brevis and consists of tyrocidines and gramicidins. Tyrothricin shows activity against bacteria, fungi and some viruses. Tyrothricin containing formulations are used in sore throat agents and in agents for the healing of infected superficial and small-area wounds[1].

體外研究
(In Vitro)

Tyrothricin is a mixture of polypeptides, consisting of 50%-70% tyrocidines and 25%-50% gramicidins. The group of tyrocidines is basic, cyclic peptides, whereas the fraction of gramicidins is neutral, linear peptides. Besides physiological and essential L-amino acids, the components of Tyrothricin also contain D-amino acids[1].
Tyrothricin is produced by the gram-positive aerobic sporeforming bacterium Bacillus brevis (Strain ATCC 8185) during its sporulation phase via the nonribosomal pathway[1].
The efficacy spectrum of Tyrothricin mainly covers gram-positive but also several gram-negative bacteria. Corynebacteria and staphylococci show a broader range of Tyrothricin concentrations for inhibition (2-256 μg/mL). In contrast to the gramicidin fraction alone, Tyrothricin is able to inhibit all Staphylococcus strains at a maximum concentration of 128 μg/mL. Among the gram-negative organisms, gonococci and meningococci were the most sensitive germs (96 μg/mL)[1].
Tyrothricin exerts fungicidal effects on a variety of Candida species. Tyrothricin shows an anti-infectious activity against parainfluenza virus (type Sendai)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內研究
(In Vivo)

In animal models using HSV type 1, a pre-incubation of the virus suspension with Tyrothricin could significantly decrease the lethality in mice. The effect could only be shown after a direct contact between Tyrothricin and the virus[1].
Nevertheless disruption of the integrity of eukaryotic membranes is observed at higher Tyrothricin concentrations in vitro. This effect is exemplified as hemolytic activity of Tyrothricin in in vitro studies and when applied to animals i.v.. In contrast to an intravenous (LD50 mouse: 3,7 mg/kg) and an intraperitoneal (LD50 mouse: 20-45 mg/kg) application the oral application is very well tolerated, as Tyrothricin is destroyed in the gastro-intestinal tract[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

酪絲菌素
結構分類
初始來源

Bacillus brevis
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數據
細胞實驗： 

DMSO 中的溶解度 : 100 mg/mL (超聲助溶; 吸濕的 DMSO 對產品的溶解度有顯著影響，請使用新開封的 DMSO)

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結果
工作液所需濃度 : mg/mL
純度 & 產品資料

純度: 96.4%

參考文獻
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產品名稱：
Tyrothricin
目錄號：
HY-120435
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