Helenalin

目錄號(hào): HY-119970 純度: 98.87%: FAQs
Data Sheet SDS COA 產(chǎn)品使用指南技術(shù)支持

Helenalin 是一種抗炎的倍半萜內(nèi)酯。Helenalin 通過直接靶向 p65 選擇性抑制轉(zhuǎn)錄因子 NF-κB。Helenalin 具有烷基化活性，以 NF-κB 的 p65 亞基中的半胱氨酸巰基為靶點(diǎn)，從而抑制其 DNA 結(jié)合。

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Helenalin Chemical Structure

CAS No. : 6754-13-8

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1 mg	￥5395	In-stock
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Customer Review

MCE 顧客使用本產(chǎn)品發(fā)表的 5 篇科研文獻(xiàn)

•J Autoimmun. 2022 May;129:102828. [Abstract]
•Mucosal Immunol. 2024 May 14. [Abstract]
•Front Immunol. 2022 Feb 4;13:835986. [Abstract]
•Can J Physiol Pharmacol. 2021 Nov 18;1-7. [Abstract]
•Exp Ther Med. August 26, 2021.

Helenalin 相關(guān)產(chǎn)品

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

生物活性
純度 & 產(chǎn)品資料
參考文獻(xiàn)

生物活性

Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor NF-κB by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding^[1]^[2].

細(xì)胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A-431	IC₅₀	0.8 μM Compound: helenalin	Cytotoxicity against human A431 cells after 72 hrs by [3H]thymidine incorporation assay Cytotoxicity against human A431 cells after 72 hrs by [3H]thymidine incorporation assay	[PMID: 10425121]
A-431	IC₅₀	0.9 μM Compound: helenalin	Cytotoxicity against human A431 cells after 24 hrs by [3H]thymidine incorporation assay Cytotoxicity against human A431 cells after 24 hrs by [3H]thymidine incorporation assay	[PMID: 10425121]
A-431	IC₅₀	0.9 μM Compound: helenalin	Cytotoxicity against human A431 cells after 48 hrs by [3H]thymidine incorporation assay Cytotoxicity against human A431 cells after 48 hrs by [3H]thymidine incorporation assay	[PMID: 10425121]
HCT-15	IC₅₀	0.29 μM Compound: Helenalin	Cytotoxicity against human HCT15 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human HCT15 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 22574648]
HeLa	EC₅₀	0.7 μM Compound: Helenalin	Cytotoxicity against human HeLa cells by MTT assay Cytotoxicity against human HeLa cells by MTT assay	[PMID: 28958621]
HEp-2	ED₅₀	0.08 μg/mL Compound: 1	Cytotoxicity against human Hep2 cells assessed as growth inhibition by microtiter method Cytotoxicity against human Hep2 cells assessed as growth inhibition by microtiter method	[PMID: 671468]
HEp-2	ED₅₀	0.08 μg/mL Compound: 1	Cytotoxicity against human Hep2 cells assessed a growth inhibition by rapid microtiter technique Cytotoxicity against human Hep2 cells assessed a growth inhibition by rapid microtiter technique	[PMID: 691008]
HEp-2	IC₅₀	0.8 μM Compound: helenalin	Cytotoxicity against human HEP2 cells after 72 hrs by [3H]thymidine incorporation assay Cytotoxicity against human HEP2 cells after 72 hrs by [3H]thymidine incorporation assay	[PMID: 10425121]
HEp-2	IC₅₀	0.9 μM Compound: helenalin	Cytotoxicity against human HEP2 cells after 24 hrs by [3H]thymidine incorporation assay Cytotoxicity against human HEP2 cells after 24 hrs by [3H]thymidine incorporation assay	[PMID: 10425121]
HEp-2	IC₅₀	0.9 μM Compound: helenalin	Cytotoxicity against human HEP2 cells after 48 hrs by [3H]thymidine incorporation assay Cytotoxicity against human HEP2 cells after 48 hrs by [3H]thymidine incorporation assay	[PMID: 10425121]
HL-60	IC₅₀	0.32 μM Compound: helenalin	Cytotoxicity against human HL-60 cells after 5 hrs by MTT assay Cytotoxicity against human HL-60 cells after 5 hrs by MTT assay	[PMID: 10425121]
HL-60	IC₅₀	0.7 μM Compound: helenalin	Cytotoxicity against human HL60 after 20 hrs by WST1 assay Cytotoxicity against human HL60 after 20 hrs by WST1 assay	[PMID: 16499337]
HL-60	IC₅₀	4 μM Compound: Helenalin	Inhibition of telomerase in human HL60 cells by TRAP assay Inhibition of telomerase in human HL60 cells by TRAP assay	10.1039/C0MD00241K
Jurkat	IC₅₀	0.46 μM Compound: helenalin	Cytotoxicity against human Jurkat T cells after 20 hrs by WST1 assay Cytotoxicity against human Jurkat T cells after 20 hrs by WST1 assay	[PMID: 16499337]
Jurkat	IC₅₀	4 μM Compound: Helenalin	Inhibition of telomerase in human Jurkat cells by TRAP assay Inhibition of telomerase in human Jurkat cells by TRAP assay	10.1039/C0MD00241K
K562	IC₅₀	0.28 μM Compound: Helenalin	Cytotoxicity against human K562 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human K562 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 22574648]
MCF7	IC₅₀	0.5 μM Compound: helenalin	Cytotoxicity against human MCF7 cells after 48 hrs by [3H]thymidine incorporation assay Cytotoxicity against human MCF7 cells after 48 hrs by [3H]thymidine incorporation assay	[PMID: 10425121]
MCF7	IC₅₀	0.7 μM Compound: helenalin	Cytotoxicity against human MCF7 cells after 72 hrs by [3H]thymidine incorporation assay Cytotoxicity against human MCF7 cells after 72 hrs by [3H]thymidine incorporation assay	[PMID: 10425121]
MCF7	IC₅₀	0.8 μM Compound: helenalin	Cytotoxicity against human MCF7 cells after 24 hrs by [3H]thymidine incorporation assay Cytotoxicity against human MCF7 cells after 24 hrs by [3H]thymidine incorporation assay	[PMID: 10425121]
OVCAR-3	IC₅₀	1.4 μM Compound: helenalin	Cytotoxicity against human OVCAR-3 cells after 24 hrs by [3H]thymidine incorporation assay Cytotoxicity against human OVCAR-3 cells after 24 hrs by [3H]thymidine incorporation assay	[PMID: 10425121]
OVCAR-3	IC₅₀	1.6 μM Compound: helenalin	Cytotoxicity against human OVCAR-3 cells after 48 hrs by [3H]thymidine incorporation assay Cytotoxicity against human OVCAR-3 cells after 48 hrs by [3H]thymidine incorporation assay	[PMID: 10425121]
OVCAR-3	IC₅₀	1.7 μM Compound: helenalin	Cytotoxicity against human OVCAR-3 cells after 72 hrs by [3H]thymidine incorporation assay Cytotoxicity against human OVCAR-3 cells after 72 hrs by [3H]thymidine incorporation assay	[PMID: 10425121]
SK-LU-1	IC₅₀	0.21 μM Compound: Helenalin	Cytotoxicity against human SKLU1 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human SKLU1 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 22574648]
SK-MEL-28	IC₅₀	0.5 μM Compound: helenalin	Cytotoxicity against human SK MEL28 cells after 72 hrs by [3H]thymidine incorporation assay Cytotoxicity against human SK MEL28 cells after 72 hrs by [3H]thymidine incorporation assay	[PMID: 10425121]
SK-MEL-28	IC₅₀	0.9 μM Compound: helenalin	Cytotoxicity against human SK MEL28 cells after 48 hrs by [3H]thymidine incorporation assay Cytotoxicity against human SK MEL28 cells after 48 hrs by [3H]thymidine incorporation assay	[PMID: 10425121]
SK-MEL-28	IC₅₀	1.3 μM Compound: helenalin	Cytotoxicity against human SK MEL28 cells after 24 hrs by [3H]thymidine incorporation assay Cytotoxicity against human SK MEL28 cells after 24 hrs by [3H]thymidine incorporation assay	[PMID: 10425121]
SW872	IC₅₀	1.2 μM Compound: helenalin	Cytotoxicity against human SW872 cells after 48 hrs by [3H]thymidine incorporation assay Cytotoxicity against human SW872 cells after 48 hrs by [3H]thymidine incorporation assay	[PMID: 10425121]
SW872	IC₅₀	1.2 μM Compound: helenalin	Cytotoxicity against human SW872 cells after 72 hrs by [3H]thymidine incorporation assay Cytotoxicity against human SW872 cells after 72 hrs by [3H]thymidine incorporation assay	[PMID: 10425121]
SW872	IC₅₀	1.4 μM Compound: helenalin	Cytotoxicity against human SW872 cells after 24 hrs by [3H]thymidine incorporation assay Cytotoxicity against human SW872 cells after 24 hrs by [3H]thymidine incorporation assay	[PMID: 10425121]
ZR-75-1	IC₅₀	0.7 μM Compound: helenalin	Cytotoxicity against human ZR-75-1 cells after 24 hrs by [3H]thymidine incorporation assay Cytotoxicity against human ZR-75-1 cells after 24 hrs by [3H]thymidine incorporation assay	[PMID: 10425121]
ZR-75-1	IC₅₀	0.8 μM Compound: helenalin	Cytotoxicity against human ZR-75-1 cells after 48 hrs by [3H]thymidine incorporation assay Cytotoxicity against human ZR-75-1 cells after 48 hrs by [3H]thymidine incorporation assay	[PMID: 10425121]
ZR-75-1	IC₅₀	1.1 μM Compound: helenalin	Cytotoxicity against human ZR-75-1 cells after 72 hrs by [3H]thymidine incorporation assay Cytotoxicity against human ZR-75-1 cells after 72 hrs by [3H]thymidine incorporation assay	[PMID: 10425121]

體外研究
(In Vitro)

Helenalin (10 μM；20-120 分鐘) 在 80 分鐘后完全抑制 NF-κB DNA 結(jié)合^[1]。
Helenalin 是一種抗炎、抗癌的植物化學(xué)物質(zhì)，是一種周期性 Skp2 積累的有效抑制劑，一種 F-box 蛋白，在 S 期進(jìn)展期間介導(dǎo) SCF E3 連接酶泛素化和兩種 CKI 的降解^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	Jurkat T cells
Concentration:	10 μM
Incubation Time:	20-120 minutes
Result:	Caused complete inhibition of NF-κB DNA binding after 80 minutes.

體內(nèi)研究
(In Vivo)

Helenalin (25 mg/kg；腹腔注射；6 至 12 小時(shí)) 對(duì)未成熟的雄性 ICR 小鼠給藥，導(dǎo)致肝臟谷胱甘肽水平迅速下降^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Immature male ICR mice^[2]
Dosage:	25 mg/kg
Administration:	i.p.; 6 to 12 hours
Result:	Caused a rapid decrease in hepatic glutathione levels.

分子量

262.30

Formula

C₁₅H₁₈O₄

CAS 號(hào)

6754-13-8

性狀

固體

顏色

White to yellow

結(jié)構(gòu)分類

初始來源

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性數(shù)據(jù)

細(xì)胞實(shí)驗(yàn)：

DMSO 中的溶解度 : 100 mg/mL (381.24 mM; 超聲助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開封的 DMSO)

配制儲(chǔ)備液

濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg

1 mM	3.8124 mL	19.0621 mL	38.1243 mL
5 mM	0.7625 mL	3.8124 mL	7.6249 mL
10 mM	0.3812 mL	1.9062 mL	3.8124 mL

查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

摩爾計(jì)算器
稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

濃度 _(start)

體積 _(start)

濃度 _(final)

體積 _(final)

動(dòng)物溶解方案計(jì)算器

請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只

由于實(shí)驗(yàn)過程有損耗，建議您多配一只動(dòng)物的量

計(jì)算結(jié)果

工作液所需濃度 : mg/mL

純度 & 產(chǎn)品資料

純度: 99.75%

選擇批次：

Data Sheet (626 KB) SDS (251 KB)

COA (297 KB) LCMS (92 KB)

產(chǎn)品使用指南 (1538 KB)

參考文獻(xiàn)

[1]. Merrill JC, et al. Role of glutathione in the toxicity of the sesquiterpene lactones hymenoxon and helenalin. J Toxicol Environ Health. 1988;23(2):159-69. [Content Brief]

[2]. Lyss G, et al. The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65. J Biol Chem. 1998 Dec 11;273(50):33508-16. [Content Brief]

[3]. Fernandes KM, et al. Helenalin-mediated post-transcriptional regulation of p21(Cip1) inhibits 3T3-L1 preadipocyteproliferation. J Cell Biochem. 2008 Oct 15;105(3):913-21. [Content Brief]

Helenalin 相關(guān)分類

完整儲(chǔ)備液配制表

可選溶劑	濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.8124 mL	19.0621 mL	38.1243 mL	95.3107 mL
	5 mM	0.7625 mL	3.8124 mL	7.6249 mL	19.0621 mL
	10 mM	0.3812 mL	1.9062 mL	3.8124 mL	9.5311 mL
	15 mM	0.2542 mL	1.2708 mL	2.5416 mL	6.3540 mL
	20 mM	0.1906 mL	0.9531 mL	1.9062 mL	4.7655 mL
	25 mM	0.1525 mL	0.7625 mL	1.5250 mL	3.8124 mL
	30 mM	0.1271 mL	0.6354 mL	1.2708 mL	3.1770 mL
	40 mM	0.0953 mL	0.4766 mL	0.9531 mL	2.3828 mL
	50 mM	0.0762 mL	0.3812 mL	0.7625 mL	1.9062 mL
	60 mM	0.0635 mL	0.3177 mL	0.6354 mL	1.5885 mL
	80 mM	0.0477 mL	0.2383 mL	0.4766 mL	1.1914 mL
	100 mM	0.0381 mL	0.1906 mL	0.3812 mL	0.9531 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Helenalin6754-13-8NF-κBNuclear factor-κBNuclear factor-kappaBDNAbindingsulfhydrylgroupsp65subunitanti-inflammatoryalkylatesInhibitorinhibitorinhibit

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Helenalin

Customer Review

MCE 顧客使用本產(chǎn)品發(fā)表的 5 篇科研文獻(xiàn)