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  2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. MPI_5a

MPI_5a 是一種高效、選擇性的 HDAC6 抑制劑 (IC50=36 nM)。MPI_5a 對其他 HDAC 酶的抑制作用很弱。MPI_5a 抑制細(xì)胞內(nèi)酰基微管蛋白的積累的 IC50 值為 210 nM。

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MPI_5a Chemical Structure

MPI_5a Chemical Structure

CAS No. : 1259296-46-2

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規(guī)格 價格 是否有貨 數(shù)量
1 mg (16.7 mM * 200 μL in Acetonitrile) ￥3200
In-stock
5 mg (16.7 mM * 1 mL in Acetonitrile) 現(xiàn)貨 詢價

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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

MPI_5a is a potent and selective HDAC6 inhibitor (IC50=36 nM). MPI_5a weakly inhibits other HDAC isoforms. MPI_5a inhibits acyl-tubulin accumulation in cells with an IC50 value of 210 nM[1].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa IC50
210 nM
Compound: 2
Inhibition of HDAC6 in human HeLa cells assessed as reduction in K40 hyperacetylation of alpha-tubulin incubated for 6 hrs by immunofluorescence assay
Inhibition of HDAC6 in human HeLa cells assessed as reduction in K40 hyperacetylation of alpha-tubulin incubated for 6 hrs by immunofluorescence assay
[PMID: 25454270]
HeLa IC50
210 nM
Compound: 5a
Inhibition of HDAC6 in human HeLa cells using acetyl tubulin as substrate assessed as Ac-Lys accumulation in nuclear histones after 6 hrs by immunofluorescence assay
Inhibition of HDAC6 in human HeLa cells using acetyl tubulin as substrate assessed as Ac-Lys accumulation in nuclear histones after 6 hrs by immunofluorescence assay
[PMID: 23964961]
分子量

299.32

Formula

C16H17N3O3
CAS 號
性狀

液體

顏色

Colorless to light yellow

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Solution, -20°C, 2 years
純度 & 產(chǎn)品資料

純度: ≥99.0%

參考文獻(xiàn)

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產(chǎn)品名稱：
MPI_5a
目錄號：
HY-113957
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