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  2. Antibody-drug Conjugate/ADC Related
  3. ADC Cytotoxin
  4. DC1SMe

DC1Sme 是 DC1 的衍生物，其對(duì) Ramos、Namalwa、HL60/s 和 COLO 205 癌細(xì)胞的 IC50 值分別為 22 pM、10 pM、32 pM 和 250 pM。DC1 是結(jié)合 DNA 小溝的烷化劑 CC-1065 的類似物，是一種 ADC 毒性小分子，可用于合成抗體偶聯(lián)物，靶向癌癥研究。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

DC1SMe Chemical Structure

DC1SMe Chemical Structure

CAS No. : 501666-85-9

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥6000
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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

DC1Sme, a DC1 derivative, exhibits IC50 values of 22 pM, 10 pM, 32 pM and 250 pM for Ramos, Namalwa, HL60/s and COLO 205 cancer cells, respectively. DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is a ADC Cytotoxin. DC1 can be used in synthesis of antibody-drug conjugates for the targeted treatment of cancer.

IC50 & Target

Duocarmycins

 

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
COLO 205 IC50
250 pM
Compound: 23, DC1SMe
Cytotoxicity against human COLO205 cells assessed as cell survival after 72 hrs by clonogenic assay
Cytotoxicity against human COLO205 cells assessed as cell survival after 72 hrs by clonogenic assay
[PMID: 22148292]
HL-60 IC50
32 pM
Compound: 23, DC1SMe
Cytotoxicity against human HL60 cells assessed as cell survival after 72 hrs by clonogenic assay
Cytotoxicity against human HL60 cells assessed as cell survival after 72 hrs by clonogenic assay
[PMID: 22148292]
NAMALVA IC50
10 pM
Compound: 23, DC1SMe
Cytotoxicity against human NAMALWA cells assessed as cell survival after 72 hrs by clonogenic assay
Cytotoxicity against human NAMALWA cells assessed as cell survival after 72 hrs by clonogenic assay
[PMID: 22148292]
Ramos IC50
22 pM
Compound: 23, DC1SMe
Cytotoxicity against human Ramos cells assessed as cell survival after 72 hrs by clonogenic assay
Cytotoxicity against human Ramos cells assessed as cell survival after 72 hrs by clonogenic assay
[PMID: 22148292]
分子量

684.23

Formula

C35H30ClN5O4S2
CAS 號(hào)
性狀

固體

顏色

Light yellow to yellow

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

純度 & 產(chǎn)品資料

純度: ≥98.0%

參考文獻(xiàn)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Inquiry Information

產(chǎn)品名稱：
DC1SMe
目錄號(hào)：
HY-112898
需求量：