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  2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. Carbacyclin

Carbacyclin  (Synonyms: Carbaprostacyclin; Carba-PGI2)

目錄號: HY-112322 純度: 98.00%
COA 產(chǎn)品使用指南 技術(shù)支持

Carbacyclin 是 PGI2 的類似物，為前列腺環(huán)素 (prostacyclin (PGI2)) 受體激動劑和血管舒張劑，能夠有效抑制血小板聚集；Carbacyclin 同時可以通過 PPARδ 來誘導(dǎo) CPT-1 mRNA 的表達(dá)，不依賴 IP 受體信號通路。

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Carbacyclin Chemical Structure

Carbacyclin Chemical Structure

CAS No. : 69552-46-1

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規(guī)格 價格 是否有貨 數(shù)量
100 μg (2.85 mM * 100 μL in Methyl acetate) ￥2250
In-stock
500 μg (2.85 mM * 500 μL in Methyl acetate) ￥3900
In-stock

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Customer Review

查看 Prostaglandin Receptor 亞型特異性產(chǎn)品:

  • 生物活性

  • 實驗參考方法

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Carbacyclin is a PGI2 analogue, acts as a prostacyclin (PGI2) receptor agonist and vasodilator, and potently inhibits platelet aggregation.

IC50 & Target

PGI2 Receptor

 

體外研究
(In Vitro)

Carbacyclin is an agonist of prostacyclin (PGI2) receptor[1]. Carbacyclin acts as an inhibitor of platelet aggregation induced by ADP or collagen in vitro[2]. Carbacyclin is a PGI2 analogue, activates CPT-1 mRNA expression through PPARδ, independent of the IP receptor signaling pathway. Carbacyclin (0.02 μM to 20 μM) activates the IP receptor signaling pathway via PKA, and such an effect is inhibited by H-89, a PKA inhibitor. Carbacyclin (0.02-80 μM) increases PPRE promoter activity via PPARδ independent of the IP receptor signaling pathway in cardiomyocytes[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Carbacyclin is 0.03 times as active as prostacyclin on inhibiting platelet aggregation in human, dog or rabbit plasma[2]. Carbacyclin (100 μg, i.p.) induces CPT-1 mRNA expression in murine heart[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

350.49

Formula

C21H34O4
CAS 號
性狀

液體

顏色

Colorless to light yellow

中文名稱

卡巴環(huán)素
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Solution, -20°C, 2 years
純度 & 產(chǎn)品資料

純度: 98.00%

參考文獻(xiàn)
Cell Assay
[3]

Primary cultures of neonatal rat cardiomyocytes are prepared from the ventricles of 1-day-old Wistar rats, and are seeded at a density of 4 × 105/6-well plastic plates, 9 × 105/60 mm dishes, or 3 × 106/100 mm dishes with Dulbecco's modified Eagle's medium (DMEM) containing 10% fetal calf serum (FCS). After 40 h of incubation, cultured cardiomyocytes are serum-starved for 8 h before Carbacyclin stimulation.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[3]

Mice[3]
Ten to twelve week-old male C57BL/6 mice (20-25 g) are used in the experiment. Mice (n = 4) are injected intraperitoneally with 100 μg of Carbacyclin, and are sacrificed at the times indicated. The hearts are excised, and the ventricles are then homogenized with 3 mL of Isogen for the following total RNA extraction procedure[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
參考文獻(xiàn)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Carbacyclin
目錄號：
HY-112322
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