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  2. Anti-infection Metabolic Enzyme/Protease
  3. Fungal Mitochondrial Metabolism Antibiotic
  4. Myxothiazol

Myxothiazol 是一種抗真菌抗生素，是線粒體電子傳遞鏈復(fù)合體 Ⅲ (complex III or bc1 complex) 抑制劑。Myxothiazol 在0.01~3 μg/ml 濃度范圍內(nèi)可抑制許多酵母菌和真菌的生長。

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Myxothiazol Chemical Structure

Myxothiazol Chemical Structure

CAS No. : 76706-55-3

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥4200
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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Myxothiazol, an antifungal antibiotic, is a mitochondrial electron transport chain complex III (bc1 complex) inhibitor. Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml[1][2].

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.01 ng/mL
Compound: Myxothiazol
Cytotoxicity against human A549 cells after 72 hrs by SRB assay
Cytotoxicity against human A549 cells after 72 hrs by SRB assay
[PMID: 10096868]
HCT-15 IC50
0.03 ng/mL
Compound: Myxothiazol
Cytotoxicity against human HCT-15 cells after 72 hrs by SRB assay
Cytotoxicity against human HCT-15 cells after 72 hrs by SRB assay
[PMID: 10096868]
SK-MEL-2 IC50
9.7 ng/mL
Compound: Myxothiazol
Cytotoxicity against human SK-MEL-2 cells after 72 hrs by SRB assay
Cytotoxicity against human SK-MEL-2 cells after 72 hrs by SRB assay
[PMID: 10096868]
SK-OV-3 IC50
0.01 ng/mL
Compound: Myxothiazol
Cytotoxicity against human SKOV3 cells after 72 hrs by SRB assay
Cytotoxicity against human SKOV3 cells after 72 hrs by SRB assay
[PMID: 10096868]
XF498 IC50
0.03 ng/mL
Compound: Myxothiazol
Cytotoxicity against human XF498 cells after 72 hrs by SRB assay
Cytotoxicity against human XF498 cells after 72 hrs by SRB assay
[PMID: 10096868]
體外研究
(In Vitro)

Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml[2].
? Myxothiazol binds to the ubiquinol oxidation site Qo of complex III and blocks electron transfer from ubiquinol to cytochrome b and thus inhibits complex III activity[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Myxothiazol (i.p.; 0.56 mg/kg; daily for 4 days)-induced complex III inhibition can be induced in mice for four days in a row without overt hepatotoxicity or lethality[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl/J6 mice[3]
Dosage: 0.56 mg/kg
Administration: I.p.; 24 hours intervals for at most 4 times
Result: A reversible complex III activity decrease to 50% of control value occurred at 2 h post-injection. At 74 h only minor histological changes in the liver were found, supercomplex formation was preserved and no significant changes in the expression of genes indicating hepatotoxicity or inflammation were found.
分子量

487.68

Formula

C25H33N3O3S2
CAS 號
性狀

固體

顏色

White to off-white

結(jié)構(gòu)分類
初始來源

Myxococcus fulvus
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性數(shù)據(jù)
細胞實驗： 

Chloroform 中的溶解度 : 10 mg/mL (20.51 mM; 超聲加熱助溶)

Chloroform 中的溶解度 : 10 mg/mL (20.51 mM; 超聲加熱助溶)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.0505 mL 10.2526 mL 20.5052 mL
5 mM 0.4101 mL 2.0505 mL 4.1010 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.53%

參考文獻

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
Chloroform / Chloroform 1 mM 2.0505 mL 10.2526 mL 20.5052 mL 51.2631 mL
5 mM 0.4101 mL 2.0505 mL 4.1010 mL 10.2526 mL
10 mM 0.2051 mL 1.0253 mL 2.0505 mL 5.1263 mL
15 mM 0.1367 mL 0.6835 mL 1.3670 mL 3.4175 mL
20 mM 0.1025 mL 0.5126 mL 1.0253 mL 2.5632 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Myxothiazol
目錄號：
HY-112177
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