成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

  2. Cell Cycle/DNA Damage Epigenetics
  3. Sirtuin
  4. CHIC35

CHIC35 是 EX-527 的結(jié)構(gòu)類似物，是 SIRT1 (IC50=0.124 μM) 的有效選擇性抑制劑。CHIC35 對(duì) SIRT1 的選擇性遠(yuǎn)大于對(duì) SIRT2 (IC50=2.8 μM) 和 SIRT3 (IC50>100 μM)。CHIC35 具有抗炎作用，可用于 CHARGE 綜合征的研究。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

CHIC35 Chemical Structure

CHIC35 Chemical Structure

CAS No. : 848193-72-6

1.  客戶無(wú)需承擔(dān)相應(yīng)的運(yùn)輸費(fèi)用。

2.  同一機(jī)構(gòu)（單位）同一產(chǎn)品試用裝僅限申領(lǐng)一次，同一機(jī)構(gòu)（單位）一年內(nèi)

     可免費(fèi)申領(lǐng)三個(gè)不同產(chǎn)品的試用裝。

3.  試用裝只面向終端客戶。

規(guī)格 是否有貨
50 mg   詢價(jià)  
100 mg   詢價(jià)  
250 mg   詢價(jià)  

* Please select Quantity before adding items.

Customer Review

查看 Sirtuin 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

CHIC35, an analog of EX-527, is a potent and selective inhibitor of SIRT1 (IC50=0.124 μM). CHIC35 shows potential selective inhibition against SIRT1 over SIRT2 (IC50=2.8 μM) or SIRT3 (IC50>100 μM)[1]. CHIC35 has anti-inflammatory?effects and can be used for CHARGE syndrome research[1][2].

IC50 & Target

SIRT1

0.124 μM (IC50)

SIRT2

2.8 μM (IC50)

SIRT3

>100 μM (IC50)

體外研究
(In Vitro)

CHIC-35 (0.5?μM; 16 hours) increases?acetylation?of?histone H4?in BMDMs similar to Cambinol (200?μM)[1].
CHIC-35 (5?μM; 72 hours) exhibits no significant difference in the survival of embryos at early stages[2].
Zebrafish embryos are microinjected with 2.4?ng of?chd7?MO to develop to different stages of development. chd7?morphant embryos are treated with CHIC-35 from 8hpf to 24hpf. CHIC-35 (5?μM) is removed at 24hpf and embryos are incubated in fresh egg water until 4dpf.?The?chd7?morphant larvae has a severely reduced and disrupted pattern of cartilage elements in comparison to the control, CHIC-35 shows partial recovery in craniofacial cartilage elements[2].
At 4dpf, zebrafish embryos show a well-formed lower jaw in controls, while?chd7 morphants exhibits reduced lower jaw. Treatment with CHIC-35 (5?μM) rescues the expression of?sox9a?inchd7 morphants[2].
Nearly 30% of?chd7?morphant embryos (24hpf to 72hpf) shows a near complete loss of?isl2a?expression in the cranial region compared to 10% of the wildtype controls. CHIC-35 reduces this to 7.5% significantly. However, CHIC-35 shows no discernible effect on the enteric neurons marked by?Tg[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

262.73

Formula

C14H15ClN2O
CAS 號(hào)
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻(xiàn)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的產(chǎn)品:

Your information is safe with us. * Required Fields.

   產(chǎn)品名稱：

  

* 需求量：

* 客戶姓名：

 

* Email：

* 電話：

 

* 公司或機(jī)構(gòu)名稱：

   留言給我們：

Bulk Inquiry

Inquiry Information

產(chǎn)品名稱：
CHIC35
目錄號(hào)：
HY-111303
需求量：