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  2. Immunology/Inflammation Apoptosis Autophagy
  3. Toll-like Receptor (TLR) TNF Receptor Interleukin Related Autophagy
  4. Resatorvid

Resatorvid  (Synonyms: 瑞沙托維; TAK-242; CLI-095)

目錄號: HY-11109 純度: 99.10%
COA 產(chǎn)品使用指南 技術(shù)支持

Resatorvid (TAK-242) 是一種選擇性的 TLR4 信號傳導(dǎo)抑制劑。Resatorvid 抑制 NO，TNF-α 和 IL-6 的產(chǎn)生，其 IC50 值分別為 1.8 nM，1.9 nM，1.3 nM。Resatorvid 下調(diào) TLR4 下游信號分子 MyD88 和 TRIF 的表達(dá)。Resatorvid 抑制自噬 (autophagy)，并在各種炎癥性疾病中起關(guān)鍵作用。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務(wù)

Resatorvid Chemical Structure

Resatorvid Chemical Structure

CAS No. : 243984-11-4

1.  客戶無需承擔(dān)相應(yīng)的運輸費用。

2.  同一機構(gòu)（單位）同一產(chǎn)品試用裝僅限申領(lǐng)一次，同一機構(gòu)（單位）一年內(nèi)

     可免費申領(lǐng)三個不同產(chǎn)品的試用裝。

3.  試用裝只面向終端客戶。

規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥1210
In-stock
5 mg ￥1100
In-stock
10 mg ￥1700
In-stock
50 mg ￥5800
In-stock
100 mg 現(xiàn)貨 詢價
200 mg   詢價  
500 mg   詢價  

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Customer Review

Other Forms of Resatorvid:

MCE 顧客使用本產(chǎn)品發(fā)表的 385 篇科研文獻(xiàn)

WB
IF
IHC
Proliferation Assay

    Resatorvid purchased from MCE. Usage Cited in: Metabolites. 2022, 12(11), 1132

    Resatorvid (TAK-242; 0.1, 1, 10, 50 μM; 24 h) inhibits the proliferation of B16 cells and A375 cells in a dose-dependent manner.

    Resatorvid purchased from MCE. Usage Cited in: Anesthesiology. 2019 Feb;130(2):292-308.   [Abstract]

    Detection of PCNA by western blotting with the treatment of 2DG, MET and COM.

    Resatorvid purchased from MCE. Usage Cited in: Anesthesiology. 2019 Feb;130(2):292-308.   [Abstract]

    The detection of cell cycle-related proteins by western blotting with the treatment of 2DG, MET and COM.

    Resatorvid purchased from MCE. Usage Cited in: Anesthesiology. 2019 Feb;130(2):292-308.   [Abstract]

    Detection of PCNA by immunohistochemistry with the treatment of 2DG, MET and COM.

    Resatorvid purchased from MCE. Usage Cited in: Anesthesiology. 2019 Feb;130(2):292-308.   [Abstract]

    Detection of activated signaling molecules in the mTOR pathway via western blotting with the treatment of 2DG, MET and COM.

    Resatorvid purchased from MCE. Usage Cited in: Anesthesiology. 2019 Feb;130(2):292-308.   [Abstract]

    The detection of activated signaling molecules of the ERK pathway via western blotting with the treatment of 2DG, MET and COM.

    Resatorvid purchased from MCE. Usage Cited in: Anesthesiology. 2019 Feb;130(2):292-308.   [Abstract]

    Detection of the expression of key glucose metabolism enzymes via western blotting with the treatment of 2DG, MET and COM.

    Resatorvid purchased from MCE. Usage Cited in: Chem Biol Interact. 2019 Feb 1;299:179-185.  [Abstract]

    Western blot analysis of TLR4 and MyD88 showing effect of TLR4 inhibitor (CLI-095) on PQ-induced inflammation in BV2 microglia. The blots are representative of three independent experiments. The bar diagrams which reflect mean fold change in the expression levels of TLR4 and MyD88 with respect to the control.

    Resatorvid purchased from MCE. Usage Cited in: FASEB J. 2019 Mar;33(3):3451-3464.  [Abstract]

    Western blot analyses of TLR4 and MAP4K4, and moesin phosphorylation in HRMECs with the different treatments of TAK-242 or LPS.

    Resatorvid purchased from MCE. Usage Cited in: FASEB J. 2019 Mar;33(3):3451-3464.  [Abstract]

    Western blot analyses of TLR4 and MAP4K4 in the retina of PN 17 OIR mice with or without TAK-242 treatment.

    Resatorvid purchased from MCE. Usage Cited in: Front Physiol. 2019 Mar 1;10:165.  [Abstract]

    Effect of EP and TAK-242 treatment on CD68 protein expressions in aortic sinus of CUMS ApoE-/- mice. Over a 16-week period treatment, entire aorta from the aortic root to the iliac bifurcation is harvested, and then frozen-sections of aortic sinus are performed for immunofluorescent staining of CD68. Representative images of CD68 expression in aortic sinus.

    Resatorvid purchased from MCE. Usage Cited in: EBioMedicine. 2018 Nov;37:78-90.  [Abstract]

    TAK-242 alters NF-κB downstream targets in PSAP overexpressing SNB19 and GSC-21 cells as measured by western blotting.

    Resatorvid purchased from MCE. Usage Cited in: Carbohyd Polym. 2018 Mar 1;183:207-218.  [Abstract]

    TAK-242 significantly reduces the protein expression of p-JNK, p-ERK, p-p38, p-Akt and LC3-II.

    Resatorvid purchased from MCE. Usage Cited in: J Neuroinflammation. 2018 Sep 4;15(1):252.  [Abstract]

    The phosphorylation of NF-κB p65 evoked by Mrp14 is decreased after TAK-242 treatment.

    Resatorvid purchased from MCE. Usage Cited in: Transplantation. 2018 Sep;102(9):1505-1513.  [Abstract]

    Whole-islet lysates are prepared from islets with (TAK) or without (CTRL) early TLR4 blockade immediately after isolation (0 hours) and at 6- and 24-hours postisolation. Lysates are immunoblotted for ERK1/2, P38, SAPK, and P65, and analyzed for relative activation (phospho:total) normalized to β-actin.

    Resatorvid purchased from MCE. Usage Cited in: Cancer Sci. 2018 Aug;109(8):2391-2400.  [Abstract]

    A549 cells pretreated with or without 5 μM TAK-242 and/or 10 μM PP1 (Src inhibitor) for 1 h are treated with 50 ng/mL Resistin for 15 min. Total protein is isolated and expression of phosphorylated (p-)Src, Src, p-EGFR, and EGFR is detected by Western blot

    Resatorvid purchased from MCE. Usage Cited in: Front Immunol. 2018 Jul 23;9:1667.  [Abstract]

    The inhibitory effect of TAK-242 on the TLR4 mRNA and protein expression is detected by RT-qPCR and Western Blot in NR8383 cells.

    Resatorvid purchased from MCE. Usage Cited in: Front Pharmacol. 2018 Jan 30;9:28.  [Abstract]

    Effects of TAK-242 on the protein expressions of TLR4, MyD88, TRAF6, p-NF-κB p65, and total NF-κB p65 induced by Aβ1-42 in hBMECs by Western blotting analysis. The bands of TLR4, MyD88, TRAF6, p-NF-κB p65, total NF-κB p65, and β-actin. β-actin is used as a loading control.

    Resatorvid purchased from MCE. Usage Cited in: Int Immunopharmacol. 2018 Aug;61:266-276.  [Abstract]

    The protein expressions of TLR4 and NF-κB p65 are measured by western blot.

    Resatorvid purchased from MCE. Usage Cited in: Sci Rep. 2018 Jan 24;8(1):1535.  [Abstract]

    Effect of TAK242 on MAPKs phosphorylation in HUVECs treated with 9t18:1 and 11t18:1. HUVECs are treated with TAK242 (0.5, 1, 1.5?μM) for 30?min and then cultured with 9t18:1 for 24?h.

    Resatorvid purchased from MCE. Usage Cited in: Cell Immunol. 2018 Jun;328:86-92.  [Abstract]

    Washed platelets are dealt with LPS (10 ug/mL, 30 min), LPS (10 ug/mL, 30 min) and TAK242 (132 nM, 30 min) or vehicle. PKC, AKT and p38 are detected by western blotting.

    Resatorvid purchased from MCE. Usage Cited in: Cancer Prev Res (Phila). 2018 May;11(5):265-278.  [Abstract]

    There is a remarkable reduction in average levels of p21waf1 expression in the Prevention tumors compared to controls.

    Resatorvid purchased from MCE. Usage Cited in: J Mol Neurosci. 2018 Dec;66(4):535-546.  [Abstract]

    In SC, p-NF-κB production is inhibited by TRAM1 siRNA or TAK242.

    Resatorvid purchased from MCE. Usage Cited in: J Mol Neurosci. 2018 Dec;66(4):535-546.  [Abstract]

    In DRG, p-NF-κB production is inhibited by TRAM1 siRNA or TAK242.

    Resatorvid purchased from MCE. Usage Cited in: J Mol Neurosci. 2018 Dec;66(4):535-546.  [Abstract]

    The increasing of TRAM1 is reversed by TAK242.

    Resatorvid purchased from MCE. Usage Cited in: Neurosci Lett. 2018 Nov 1;686:33-40.   [Abstract]

    Western Blot analyses show the protein expression of MCPIP1 after the treatment of PBS and LPS (with TAK-242, C29, FPS-ZM1).

    Resatorvid purchased from MCE. Usage Cited in: Neurosci Lett. 2018 Nov 1;686:33-40.   [Abstract]

    Images show the expression of MCPIP1 after the treatment of of PBS and LPS (with TAK-242, C29, FPS-ZM1).

    Resatorvid purchased from MCE. Usage Cited in: Cell Physiol Biochem. 2018;47(4):1497-1508.  [Abstract]

    TAK-242 inhibits coronary microembolization (CME)-induced TLR4 upregulation and NLRP3 inflammasome activation.

    Resatorvid purchased from MCE. Usage Cited in: Oxid Med Cell Longev. 2018 May 16;2018:6296802.  [Abstract]

    HK-2 cells are treated with TLR4 inhibitor (TAK242, 5?μM) for 2?h prior to HG (30?mM) treatment for 2?h and with NF-κB blocker (Parthenolide, 10?μM) and HG (30?mM) for 2?h, and the samples are collected for Western blot analysis.

    Resatorvid purchased from MCE. Usage Cited in: Chin Med J (Engl). 2017 Apr 20;130(8):906-913.  [Abstract]

    The levels of TLR4, IL-1β mRNA, and protein in TAK242 group are much lower than those in IgANTAK242 group.

    Resatorvid purchased from MCE. Usage Cited in: Life Sci. 2017 Feb 1;170:25-32.  [Abstract]

    Inhibition of TLR4 signaling attenuates PQ-induced NF-?B activation and cytokine production. A549 cells are pre-treated 1 ?M TAK-242, followed by treatment with 300 ?M PQ for 24 h. The levels of (A) p-I?B, (B) nuclear NF-?B and (C) TLR4 are examined by Western blot analysis. (D) The relative mRNA expressions of TNF-?, IL-1??and IL-6 are measured by real-time PCR.

    Resatorvid purchased from MCE. Usage Cited in: Front Immunol. 2017 Dec 13;8:1808.  [Abstract]

    The protein expression levels of Tgm2 in the 8-week Sj-infected mouse liver with TAK242 treatment are significantly reduced compared to those of the non-treated control.

    Resatorvid purchased from MCE. Usage Cited in: Sci Rep. 2017 Mar 8;7:43834.  [Abstract]

    Compared with the expression in the DM?+?MCAO group, the expression of Bcl-2, Bax, cleaved caspase-3, TNF-α, IL-1β and TLR4 proteins is greatly reduced in the DM?+?MCAO?+?TAK242 group.

    Resatorvid purchased from MCE. Usage Cited in: PLoS One. 2017 May 24;12(5):e0178147.  [Abstract]

    (A) Titration of TAK-242 concentration. RPTC cells are cultured for 12 h in low glucose or high glucose medium with or without TAK-242. (B) MyD88 upregulation is also inhibited by TAK-242 under high glucose conditions by Western blotting.

    Resatorvid purchased from MCE. Usage Cited in: Mol Med Rep. 2017 Sep;16(3):3111-3116.  [Abstract]

    TLR4 inhibitor TAK 242 suppresses the TLR4/IRAK/NF ΚB signaling pathway in PASMCs. Western blot analysis is performed to detect the levels of p IRAK, IRAK, p IKK, IKK, p IκB, IκB and NF κB p65, and the representative blot results are shown.

    Resatorvid purchased from MCE. Usage Cited in: Graefes Arch Clin Exp Ophthalmol. 2017 Nov;255(11):2199-2210.  [Abstract]

    The effect of TAK-242 on the expression levels of TRAF6 and NLRP3 in retinal ganglion cells (RGCs) under high glucose are detected by Western blotting.

    Resatorvid purchased from MCE. Usage Cited in: Graefes Arch Clin Exp Ophthalmol. 2017 Nov;255(11):2199-2210.  [Abstract]

    The effect of TAK-242 on the expression levels of NF-κB and MyD88 in retinal ganglion cells (RGCs) under high glucose are detected by Western blotting.

    Resatorvid purchased from MCE. Usage Cited in: Oncotarget. 2017 May 9;8(19):31802-31814.  [Abstract]

    Activation of the β-catenin signaling pathway by Fn (F01) can be inhibited by both the TLR4 inhibitor (TAK-242) and PAK1 inhibitor (IPA-3).

    Resatorvid purchased from MCE. Usage Cited in: Cell Physiol Biochem. 2017;41(4):1675-1683.  [Abstract]

    NF-κB p65 (nuclei) protein expression detected by western blot.

    Resatorvid purchased from MCE. Usage Cited in: Cell Physiol Biochem. 2017;41(4):1675-1683.  [Abstract]

    MyD88 protein expression detected by western blot.

    Resatorvid purchased from MCE. Usage Cited in: Cell Physiol Biochem. 2017;41(4):1675-1683.  [Abstract]

    TLR4 protein expression detected by western blot.

    Resatorvid purchased from MCE. Usage Cited in: Cell Physiol Biochem. 2017;41(4):1675-1683.  [Abstract]

    Cleaved caspase-3 protein expression detected by western blot.

    Resatorvid purchased from MCE. Usage Cited in: Cell Physiol Biochem. 2017;41(4):1675-1683.  [Abstract]

    p-IκBα protein expression detected by western blot.

    Resatorvid purchased from MCE. Usage Cited in: J Neurochem. 2016 May;137(4):576-88.  [Abstract]

    TAK-242 markedly inhibits the up-regulation of IRAK-M and the down-regulation of p-IRAK-1 in rHMGB1-pretreated rats underwent MCAO. WB analysis of IRAK-M and p-IRAK-1 in rat ipsilateral hemispheres.

    Resatorvid purchased from MCE. Usage Cited in: Sci Rep. 2016 Aug 4;6:30957.  [Abstract]

    SEA promotes the senescence of LX-2 cells through activation of TLR4 signaling. Western blot analysis for P-p53 or TLR4 in LX-2 cells treated with SEA or TLR4 inhibitor TAK-242 (1?nM).

    Resatorvid purchased from MCE. Usage Cited in: Sci Rep. 2016 Jun 9;6:27866.  [Abstract]

    Examination of TLR4 expression level in each group. The protein and mRNA levels of TLR4 are down-regulated by pretreatment with TAK-242.

    Resatorvid purchased from MCE. Usage Cited in: Photochem Photobiol. 2016 Nov;92(6):816-825.  [Abstract]

    Western blot analysis reveals that Resatorvid-based inhibition of TLR4 is able to block UV-induced phosphorylation of MAP kinases (p38 and JNK) and Akt.

    Resatorvid purchased from MCE. Usage Cited in: Oncol Lett. 2016 Aug;12(2):1034-1040.  [Abstract]

    Involvement of TLR4 signaling pathway in HIF-1α silencing affects inflammatory and apoptosis under hypoxic conditions. In total, 30 mg total lysate is harvested with radioimmunoprecipitation assay buffer to detect TLR4, HIF-1α, caspase-3, MyD88, p-ASK1 and p-p38 protein expression by western blot analysis in human hepatocellular carcinoma HepG2 cells. The expression of TLR4, HIF-1α, MyD88, p-ASK1 NS and p-p38 in shHIF-1α transfected cells is significantly higher compared with the parental cells.

    Resatorvid purchased from MCE. Usage Cited in: Am J Physiol Gastrointest Liver Physiol. 2016 Dec 1;311(6):G1091-G1104.  [Abstract]

    Effects of TAK 242 and Catalpol on the expression of TLR-4 and activation of Src, PI3K, FAK, and Cathepsin B induced by LPS in HUVECs. Representative Western blots of TLR-4, p-Src, Src, p-PI3K, PI3K, p-FAK, FAK, activated cathepsin B, and cathepsin B proenzyme in different groups.

    Resatorvid purchased from MCE. Usage Cited in: PLoS One. 2015 Nov 10;10(11):e0142456.  [Abstract]

    Renal protein expression of E-cadherin (an epithelial marker), and Fibronectin and a-SMA (mesenchymal markers) are assayed in rats treated with Aldo-salt or with Aldo-salt plus TAK-242. TAK-242 reverses the Aldo-salt-induced renal epithelial-mesenchymal transition.

    • 生物活性

    • 純度 & 產(chǎn)品資料

    • 參考文獻(xiàn)

    生物活性

    Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor. Resatorvid inhibits NO, TNF-α and IL-6 production with IC50s of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy and plays pivotal role in various inflammatory diseases[1][2].

    IC50 & Target[1][2]

    TLR4

     

    TNF-R

    1.9 nM (IC50)

    IL-6

    1.3 nM (IC50)

    細(xì)胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    RAW264.7 IC50
    1.3 nM
    Compound: (R)-(+)-5n
    Inhibition of LPS-induced IL6 production in mouse RAW264.7 cells by ELISA
    Inhibition of LPS-induced IL6 production in mouse RAW264.7 cells by ELISA
    		[PMID: 16279805]
    RAW264.7 IC50
    1.9 nM
    Compound: (R)-(+)-5n
    Inhibition of LPS-induced TNFalpha production in mouse RAW264.7 cells by ELISA
    Inhibition of LPS-induced TNFalpha production in mouse RAW264.7 cells by ELISA
    		[PMID: 16279805]
    體外研究
    (In Vitro)

    Resatorvid 抑制 LPS 刺激的人外周血單核細(xì)胞 (PBMC) 產(chǎn)生 NO、TNF-α 和 IL-6，IC50 值為 11 至 33 nM[1]。
    Resatorvid (1-100 nM；4 小時) 抑制 RAW264.7 細(xì)胞中 LPS 和 IFN-γ 誘導(dǎo)的 IL-6 和 TNF-α 的 mRNA 表達(dá)[1]。
    Resatorvid (1-100 nM；15 分鐘；PBMCs 細(xì)胞) 顯著抑制 LPS 誘導(dǎo)的細(xì)胞外信號調(diào)節(jié)激酶 1/2 (Erk1/2)、p38 和 JNK/SAPK 的磷酸化以及降解 IκBβ 濃度為 100 nM[1]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    RT-PCR[1]

    Cell Line: RAW264.7 cells
    Concentration: 1 nM, 10 nM, 100 nM
    Incubation Time: 4 hours
    Result: TNF-α and IL-6 mRNA expression levels were clearly suppressed at concentrations of 10 to 100 nM.

    Western Blot Analysis[1]

    Cell Line: PBMCs cells
    Concentration: 1 nM, 10 nM, 100 nM
    Incubation Time: 15 minutes
    Result: The phosphorylation of mitogen-activated protein kinases induced by LPS was also inhibited in a concentration-dependent manner.
    體內(nèi)研究
    (In Vivo)

    Resatorvid (TAK-242；3 mg/kg；腹膜內(nèi)注射；持續(xù) 2 天；雄性 C57BL/6 小鼠) 預(yù)處理可顯著且顯著地逆轉(zhuǎn) LPS 誘導(dǎo)的體重減輕、TA 肌肉損失和肌肉力量損失。TAK-242 逆轉(zhuǎn) LPS 引起的肌肉纖維收縮并增加間質(zhì)空間。TAK-242 阻斷 LPS 給藥小鼠的全身分解代謝細(xì)胞因子釋放和骨骼肌蛋白水解[3]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male C57BL/6 mice (8-12 weeks of age) treated with lipopolysaccharide (LPS)[3]
    Dosage: 3?mg/kg
    Administration: Intraperitoneal injection; for 2 days
    Result: Pretreatment of mice reduced or reversed all the detrimental effects of LPS.
    Clinical Trial
    分子量

    361.82

    Formula

    C15H17ClFNO4S
    CAS 號
    性狀

    固體

    顏色

    Off-white to yellow

    中文名稱

    瑞沙托維
    運輸條件

    Room temperature in continental US; may vary elsewhere.
    儲存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    溶解性數(shù)據(jù)
    細(xì)胞實驗： 

    DMSO 中的溶解度 : 100 mg/mL (276.38 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

    Ethanol 中的溶解度 : 20 mg/mL (55.28 mM; 超聲加熱助溶)

    配制儲備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 2.7638 mL 13.8190 mL 27.6381 mL
    5 mM 0.5528 mL 2.7638 mL 5.5276 mL
    查看完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

    • 摩爾計算器

    • 稀釋計算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質(zhì)量
    =
    濃度
    ×
    體積
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start)

    C1

    ×
    體積 (start)

    V1

    =
    濃度 (final)

    C2

    ×
    體積 (final)

    V2

    動物實驗：

    請根據(jù)您的 實驗動物和給藥方式 選擇適當(dāng)?shù)娜芙夥桨浮?

    以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：
    ——為保證實驗結(jié)果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實驗的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；
    以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

    • 方案 一

      請依序添加每種溶劑： 5% DMSO    40% PEG300    5% Tween-80    50% Saline

      Solubility: 5.5 mg/mL (15.20 mM); 懸濁液; 超聲助溶

    • 方案 二

      請依序添加每種溶劑： 5% DMSO    95% (20% SBE-β-CD in Saline)

      Solubility: 5.5 mg/mL (15.20 mM); 懸濁液; 超聲助溶

    動物溶解方案計算器
    請輸入動物實驗的基本信息：

    給藥劑量

    mg/kg

    動物的平均體重

    g

    每只動物的給藥體積

    μL

    動物數(shù)量

    只
    由于實驗過程有損耗，建議您多配一只動物的量
    請輸入您的動物體內(nèi)配方組成：
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    如果您的動物是免疫缺陷鼠或者體弱鼠，建議 DMSO 中的在最后工作液體系中的占比盡量不超過 2%。
    方案所需 助溶劑 包括：DMSO， ，均可在 MCE 網(wǎng)站選購。 ，Tween 80，均可在 MCE 網(wǎng)站選購。
    計算結(jié)果
    工作液所需濃度 : mg/mL
    儲備液配制方法 : mg 藥物溶于 μL  DMSO（母液濃度為 mg/mL）。
    您所需的儲備液濃度超過該產(chǎn)品的實測溶解度，以下方案僅供參考，如有需要，請與 MCE 中國技術(shù)支持聯(lián)系。
    動物實驗體內(nèi)工作液的配制方法 : 取 μL DMSO 儲備液，加入 μL 。 μL ，混合均勻至澄清，再加 μL Tween 80，混合均勻至澄清，再加 μL 生理鹽水。
    連續(xù)給藥周期超過半月以上，請謹(jǐn)慎選擇該方案。
    請確保第一步儲備液溶解至澄清狀態(tài)，從左到右依次添加助溶劑。您可采用超聲加熱 （超聲清洗儀，建議頻次 20-40 kHz），渦旋吹打等方式輔助溶解。
    純度 & 產(chǎn)品資料

    純度: 99.95% ee.: 98.00%

    參考文獻(xiàn)

    完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

    可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
    Ethanol / DMSO 1 mM 2.7638 mL 13.8190 mL 27.6381 mL 69.0951 mL
    5 mM 0.5528 mL 2.7638 mL 5.5276 mL 13.8190 mL
    10 mM 0.2764 mL 1.3819 mL 2.7638 mL 6.9095 mL
    15 mM 0.1843 mL 0.9213 mL 1.8425 mL 4.6063 mL
    20 mM 0.1382 mL 0.6910 mL 1.3819 mL 3.4548 mL
    25 mM 0.1106 mL 0.5528 mL 1.1055 mL 2.7638 mL
    30 mM 0.0921 mL 0.4606 mL 0.9213 mL 2.3032 mL
    40 mM 0.0691 mL 0.3455 mL 0.6910 mL 1.7274 mL
    50 mM 0.0553 mL 0.2764 mL 0.5528 mL 1.3819 mL
    DMSO 60 mM 0.0461 mL 0.2303 mL 0.4606 mL 1.1516 mL
    80 mM 0.0345 mL 0.1727 mL 0.3455 mL 0.8637 mL
    100 mM 0.0276 mL 0.1382 mL 0.2764 mL 0.6910 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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