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  2. Metabolic Enzyme/Protease
  3. Angiotensin-converting Enzyme (ACE)
  4. Imidaprilate

Imidaprilate  (Synonyms: 6366A; Imidaprilat)

目錄號: HY-109592
COA 產(chǎn)品使用指南

Imidaprilate 是 TA-6366 的有效代謝物，為血管緊張素轉(zhuǎn)化酶 (ACE) 抑制劑，可用于高血壓的研究。

MCE 的所有產(chǎn)品僅用作科學研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務

Imidaprilate Chemical Structure

Imidaprilate Chemical Structure

CAS No. : 89371-44-8

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥6950
1 - 2 周
5 mg   詢價  
10 mg   詢價  

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Customer Review

Other Forms of Imidaprilate:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Imidaprilate is an active metabolite of TA-6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC50 of 2.6 nM, and is used in the research of hypertensive disease.

IC50 & Target

IC50: 2.6 nM (ACE)[1]
體外研究
(In Vitro)

Imidaprilate (6366A) is an active metabolite of 6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC50 of 2.6 nM. Imidaprilate augments the bradykinin-induced contraction of guinea pig ileum, with AC50 of 1.7 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Imidaprilate (≥0.2 mg/kg) inhibits angiotensin I (AT-I)-induced pressor response. TA-6366 lowers the blood pressure in two-kidney one-clip renal hypertensive rats at 0.5-2 mg/kg via oral administration, and in spontaneously hypertensive rats (SHRs) at 2 to 10 mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

377.39

Formula

C18H23N3O6
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

咪達普利拉
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
純度 & 產(chǎn)品資料

純度: 96.64%

參考文獻

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Imidaprilate
目錄號：
HY-109592
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