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  2. Protein Tyrosine Kinase/RTK
  3. FLT3
  4. 3-Hydroxy Midostaurin

3-Hydroxy Midostaurin  (Synonyms: CGP52421)

目錄號: HY-108263 純度: 97.02%
COA 產(chǎn)品使用指南 技術(shù)支持

3-Hydroxy Midostaurin (CGP 52421) 是 PKC412 的代謝產(chǎn)物，可有效抑制 FMS 樣酪氨酸激酶 3 (FLT3) 自磷酸化，在培養(yǎng)基和血漿中的 IC50 分別為 132 nM 和 9.8 μM。與 PKC412 相比，3-Hydroxy Midostaurin 的選擇性較低，但細(xì)胞毒性更高。

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3-Hydroxy Midostaurin Chemical Structure

3-Hydroxy Midostaurin Chemical Structure

CAS No. : 179237-49-1

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥4680
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Other Forms of 3-Hydroxy Midostaurin:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412[1].

IC50 & Target

IC50: 132 nM (FLT3 in culture medium) and 9.8 μM (FLT3 in plasma)[1]
體外研究
(In Vitro)

CGP52421 (200, 400, 600, 800, 1000 nM) is more cytotoxic than PKC412 over the dose range 100 to 500 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

586.64

Formula

C35H30N4O5
CAS 號
性狀

固體

顏色

Light yellow to yellow

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
純度 & 產(chǎn)品資料
參考文獻(xiàn)

3-Hydroxy Midostaurin 相關(guān)分類

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
3-Hydroxy Midostaurin
目錄號：
HY-108263
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