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  2. Apoptosis Autophagy
  3. c-Myc Autophagy
  4. ML327

ML327 是 MYC 的阻斷劑，也可以去阻遏 E-鈣粘蛋白轉(zhuǎn)錄和逆轉(zhuǎn)上皮-間質(zhì)轉(zhuǎn)化 (EMT)。

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ML327 Chemical Structure

ML327 Chemical Structure

CAS No. : 1883510-31-3

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     可免費(fèi)申領(lǐng)三個(gè)不同產(chǎn)品的試用裝。

3.  試用裝只面向終端客戶(hù)。

規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥560
In-stock
5 mg ￥1400
In-stock
10 mg ￥2200
In-stock
25 mg ￥4500
In-stock
50 mg 現(xiàn)貨 詢(xún)價(jià)
100 mg 現(xiàn)貨 詢(xún)價(jià)
200 mg   詢(xún)價(jià)  
500 mg   詢(xún)價(jià)  

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Customer Review

  • 生物活性

  • 實(shí)驗(yàn)參考方法

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

ML327 is a blocker of MYC which can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).

IC50 & Target

MYC[1]
體外研究
(In Vitro)

用 ML327 處理可誘導(dǎo)神經(jīng)母細(xì)胞瘤細(xì)胞的細(xì)長(zhǎng)形態(tài)。用 ML327 處理的 BE (2)-C 細(xì)胞顯示 G1 細(xì)胞周期停滯，S 期細(xì)胞群一致減少，而亞 G0 細(xì)胞群顯著增加。ML327 在所有七種神經(jīng)母細(xì)胞瘤細(xì)胞系中誘導(dǎo) CDH1 的表達(dá)，CDH1 mRNA 表達(dá)誘導(dǎo) 50 到 1，400 倍。ML327 在所有測(cè)試的神經(jīng)母細(xì)胞瘤細(xì)胞系中阻斷致癌轉(zhuǎn)錄因子 MYC 家族的表達(dá)。免疫印跡時(shí)間進(jìn)程表明在使用 ML327 (10 μM) 處理后 2 小時(shí)內(nèi) N-MYC 表達(dá)的早期抑制。p53 水平也被 ML327 處理抑制。ML327 預(yù)處理的細(xì)胞在基于四唑鹽的 (p<0.0001) 和貼壁 2D 集落形成 (41 對(duì) 400；p<0.0001)[1]中均表現(xiàn)出降低的增殖潛力。在這些體外測(cè)定中，ML327 通過(guò) Matrigel 減少 SW620inv 細(xì)胞侵襲約 60%，并將 H520 細(xì)胞侵襲減少約 30%。在通過(guò) TGF-β1 處理誘導(dǎo)上皮-間質(zhì)轉(zhuǎn)化 (EMT) 的 NMuMG 細(xì)胞中，ML327 部分恢復(fù)質(zhì)膜上的 E-鈣粘蛋白表達(dá)[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

ML327 處理在兩周處理期間顯著減少了三倍的腫瘤體積 (p=0.02)。ML327 處理的小鼠的腫瘤外植體重量大約小三倍 (p=0.01)。用 ML327 處理的小鼠比載體處理的小鼠多失去 12% 的體重。ML327 處理導(dǎo)致 MYCN 表達(dá)降低兩倍，證實(shí) ML327 抑制異種移植物 MYCN 表達(dá) (p=0.0035)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

366.37

Formula

C19H18N4O4
CAS 號(hào)
性狀

固體

顏色

White to off-white

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 32 mg/mL (87.34 mM; 超聲加熱助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開(kāi)封的 DMSO)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.7295 mL 13.6474 mL 27.2948 mL
5 mM 0.5459 mL 2.7295 mL 5.4590 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用， -20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 98.06%

參考文獻(xiàn)
Cell Assay
[1]

Cells are seeded onto 96-well plates at equivalent density (3,000 to 10,000 depending upon cell line), permitted to attach overnight, and treated with either ML327 (10 μM) or vehicle. Daily absorbance measurements (450 nm) using the cell counting kit are obtained. For estimation of IC50 values, cells are plated at equal density, permitted to attach, and baseline absorbance is obtained using cell counting kit. Cells are then treated with varying doses of ML327 (0.1 to 30 μM) and cell viability is measured 72 h after treatment[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[1]

Male athymic nude mice (4 to 6 weeks old) are maintained as described. BE(2)-C cells xenografts are established as previously described. Briefly, 1×106 cells/100 μL of HBSS are injected subcutaneously into flanks using a 26-gauge needle (n=10 per group). Mice are monitored daily for xenograft formation and assessed by measuring the two greatest perpendicular tumor diameter with venier calipers. Xenograft volumes are estimated using the following formula [(length×width2)/2]. Once tumors reach 75 to 100 mm3, mice are randomized to receive either 50 mg/kg of ML327 or control vehicle (70% polyethylene glycol) via intraperitoneal injection twice daily for 14d. Weight and tumor volume are recorded daily. After completion of two weeks of treatment, mice are euthanized and tumors are excised, weighed, and RNA is isolated[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用， -20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7295 mL 13.6474 mL 27.2948 mL 68.2370 mL
5 mM 0.5459 mL 2.7295 mL 5.4590 mL 13.6474 mL
10 mM 0.2729 mL 1.3647 mL 2.7295 mL 6.8237 mL
15 mM 0.1820 mL 0.9098 mL 1.8197 mL 4.5491 mL
20 mM 0.1365 mL 0.6824 mL 1.3647 mL 3.4119 mL
25 mM 0.1092 mL 0.5459 mL 1.0918 mL 2.7295 mL
30 mM 0.0910 mL 0.4549 mL 0.9098 mL 2.2746 mL
40 mM 0.0682 mL 0.3412 mL 0.6824 mL 1.7059 mL
50 mM 0.0546 mL 0.2729 mL 0.5459 mL 1.3647 mL
60 mM 0.0455 mL 0.2275 mL 0.4549 mL 1.1373 mL
80 mM 0.0341 mL 0.1706 mL 0.3412 mL 0.8530 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Inquiry Information

產(chǎn)品名稱(chēng)：
ML327
目錄號(hào)：
HY-103038
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