(2R,4R)-APDC (Synonyms: (2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid)

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Data Sheet 產(chǎn)品使用指南技術(shù)支持

(2R,4R)-APDC 是一種群 II 型代謝型谷氨酸受體 (mGluR) 激動(dòng)劑。(2R,4R)-APDC 通過抑制谷氨酸釋放、增強(qiáng) D1 受體激活產(chǎn)生的運(yùn)動(dòng)反應(yīng)或降低腦源性神經(jīng)營(yíng)養(yǎng)因子 (BDNF) 的水平來影響細(xì)胞增殖。(2R,4R)-APDC 可用于癲癇和其他神經(jīng)系統(tǒng)疾病的研究。

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(2R,4R)-APDC Chemical Structure

CAS No. : 169209-63-6

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mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

生物活性
純度 & 產(chǎn)品資料
參考文獻(xiàn)

生物活性

(2R,4R)-APDC is a group II metabotropic glutamate receptor (mGluR) agonist. (2R,4R)-APDC affects cell proliferation by inhibiting glutamate release, enhancing motor responses produced by D1 receptor activation, or reducing brain-derived neurotrophic factor (BDNF) levels. (2R,4R)-APDC can be used in the study of epilepsy and other neurological diseases^[1]^[2].

IC₅₀ & Target^[1]

group II mGlu receptors

細(xì)胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	> 100 μM Compound: 18	Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive	[PMID: 15801843]

體內(nèi)研究
(In Vivo)

2R, 4R-APDC (1-10 nmol; ICV; daily for 14 days) decreases cell proliferation in the dentate gyrus^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male Sprague-Dawley rats weighing between 300 and 350 g^[2]
Dosage:	1 nmol/10 μl; 10 nmol/10μl
Administration:	ICV; daily for 14 days
Result:	Resulted in decreased BrdU-immunoreactive cells in the DG.

分子量

174.15

Formula

C₆H₁₀N₂O₄

CAS 號(hào)

169209-63-6

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

純度 & 產(chǎn)品資料

產(chǎn)品使用指南 (1538 KB)

參考文獻(xiàn)

[1]. Folbergrová J, et al. Posttreatment with group II metabotropic glutamate receptor agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate is only weakly effective on seizures in immature rats. Brain Res. 2009 Jun 1;1273:144-54. [Content Brief]

[2]. Yao H, et al. 2R, 4R-APDC decreases cell proliferation in the dentate gyrus of adult rats: the effect of 2R, 4R-APDC on cell proliferation. Neuroreport. 2007 Sep 17;18(14):1459-62. [Content Brief]

(2R,4R)-APDC 相關(guān)分類

Neurological Disease

摩爾計(jì)算器
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量		濃度		體積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

濃度 _(start)	×	體積 _(start)	=	濃度 _(final)	×	體積 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(2R,4R)-APDC169209-63-6(2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acidmGluRMetabotropic glutamate receptorsanticonvulsantneuroprotectivecellproliferationdentategyrusInhibitorinhibitorinhibit

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(2R,4R)-APDC (Synonyms: (2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid)

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(2R,4R)-APDC (Synonyms: (2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid)

Customer Review

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(2R,4R)-APDC 相關(guān)抗體

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查看 mGluR 亞型特異性產(chǎn)品:

生物活性

純度 & 產(chǎn)品資料

參考文獻(xiàn)

(2R,4R)-APDC 相關(guān)分類

摩爾計(jì)算器

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The molarity calculator equation

The dilution calculator equation

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