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  2. Anti-infection
  3. Fungal
  4. Latrunculin B

Latrunculin B  (Synonyms: 紅海海綿素 B)

目錄號: HY-101848 純度: ≥98.0%
COA 產(chǎn)品使用指南 技術(shù)支持

Latrunculin B 是一種抗菌生物堿，是一種肌動蛋白聚合 (actin polymerization) 抑制劑。Latrunculin B 調(diào)節(jié)肺靜脈電生理特征并減輕牽張性心律失常的發(fā)生?？拐婢涂乖鷦游锘钚?。

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Latrunculin B Chemical Structure

Latrunculin B Chemical Structure

CAS No. : 76343-94-7

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥4800
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10 mg   詢價(jià)  

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Customer Review

Other Forms of Latrunculin B:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Latrunculin B, an antimicrobial marine alkaloid, is an actin polymerization inhibitor. Latrunculin B regulates pulmonary vein electrophysiological characteristics and attenuates stretch-induced arrhythmogenesis. Antifungal and antiprotozoal activity[1][2].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
7.1 μM
Compound: 2, NSC-339663
Cytotoxicity against human HCT116 cells after 3 days by trypan blue assay
Cytotoxicity against human HCT116 cells after 3 days by trypan blue assay
[PMID: 18942825]
HUVEC IC50
478 nM
Compound: LatB
Inhibition of cell migration in human HUVEC cells assessed as decrease in cell velocity measured after 16 hrs by crystal violet staining based scratch assay
Inhibition of cell migration in human HUVEC cells assessed as decrease in cell velocity measured after 16 hrs by crystal violet staining based scratch assay
[PMID: 31260301]
HUVEC IC50
611.6 nM
Compound: LatB
Antiproliferative activity against human HUVEC measured after 72 hrs
Antiproliferative activity against human HUVEC measured after 72 hrs
[PMID: 31260301]
MDA-MB-435 IC50
4.8 μM
Compound: 2, NSC-339663
Cytotoxicity against human MDA-MB-435 cells 48 hrs by SRB assay
Cytotoxicity against human MDA-MB-435 cells 48 hrs by SRB assay
[PMID: 18942825]
體外研究
(In Vitro)

Latrunculin B displays growth inhibition of HeLa cells with an IC50 value of 1.4 μM[1].
Latrunculin B modulates electrophysiological characteristics and arrhythmogenesis in pulmonary vein cardiomyocytes. Latrunculin B (100 nM) decreases the spontaneous electrical activity by 16±4% in pulmonary vein (PV) preparations. Latrunculin B (100 nM) decreases the late Na+ current, L-type Ca2+ current, Na+/Ca2+ exchanger current, and stretch-activated BKCa current in PV cardiomyocytes. Latrunculin B reduces the transient outward K+ current and ultra-rapid delayed rectifier K+ current, but increases the delayed rectifier K+ current in isolated PV cardiomyocytes. Latrunculin B (100 nM) decreases intracellular Ca2+ transient and sarcoplasmic reticulum Ca2+ content in PV cardiomyocytes. Latrunculin B attenuates stretch-induced increased spontaneous electrical activity and trigger activity[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

395.51

Formula

C20H29NO5S
CAS 號
性狀

固體

顏色

Colorless to off-white

中文名稱

紅海海綿素 B
初始來源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 25 mg/mL (63.21 mM; 超聲加熱助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.5284 mL 12.6419 mL 25.2838 mL
5 mM 0.5057 mL 2.5284 mL 5.0568 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時(shí)，請?jiān)?個(gè)月內(nèi)使用，-20°C儲存時(shí)，請?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計(jì)算器
請輸入動物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實(shí)驗(yàn)過程有損耗，建議您多配一只動物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: ≥98.0%

參考文獻(xiàn)

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時(shí)，請?jiān)?個(gè)月內(nèi)使用，-20°C儲存時(shí)，請?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5284 mL 12.6419 mL 25.2838 mL 63.2095 mL
5 mM 0.5057 mL 2.5284 mL 5.0568 mL 12.6419 mL
10 mM 0.2528 mL 1.2642 mL 2.5284 mL 6.3210 mL
15 mM 0.1686 mL 0.8428 mL 1.6856 mL 4.2140 mL
20 mM 0.1264 mL 0.6321 mL 1.2642 mL 3.1605 mL
25 mM 0.1011 mL 0.5057 mL 1.0114 mL 2.5284 mL
30 mM 0.0843 mL 0.4214 mL 0.8428 mL 2.1070 mL
40 mM 0.0632 mL 0.3160 mL 0.6321 mL 1.5802 mL
50 mM 0.0506 mL 0.2528 mL 0.5057 mL 1.2642 mL
60 mM 0.0421 mL 0.2107 mL 0.4214 mL 1.0535 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Latrunculin B
目錄號：
HY-101848
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