10, 11.1 and 12.6 uM for Na, ICa, Ito and IKr currents)." />

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JNJ303

  Cat. No.:  DC23567   Featured
Chemical Structure
878489-28-2
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More than 5000 active chemicals with high quality for research!
Field of application
JNJ303 is a potent, specific delayed rectifier potassium current I(Ks) blocker with IC50 of 64 nM, shows no effects on other cardiac channels (IC50=3.3, >10, 11.1 and 12.6 uM for Na, ICa, Ito and IKr currents).
Cas No.: 878489-28-2
Chemical Name: 2-(4-Chlorophenoxy)-2-methyl-N-[5-[(methylsulfonyl)amino]tricyclo[3.3.1.13,7]dec-2-yl]-propanamide
Synonyms: JNJ 303,JNJ-303, JNJ 303
SMILES: CC(C)(C(=O)NC1[C@@H]2CC3C[C@H]1CC(C2)(C3)NS(=O)(=O)C)OC4=CC=C(C=C4)Cl
Formula: C21H29ClN2O4S
M.Wt: 440.983
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: JNJ 303 is a potent IKs blocker with an IC50 value of 64 nM. JNJ 303 does not have any effects on other cardiac channels at concentrations of 3.3 μM for INa, Ica, Ito, and IKr. JNJ 303 induces QT-prolongations and causes unprovoked torsades de pointes (TdP)[1].
Target: IC50: 64 nM (IKs)[1]
References: [1]. Julie Albrecht, et al. The effect of the KV7/KCNE 1 inhibitor JNJ 303 on heart slices and the L-type calcium channel of cardiac cells.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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