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Nutlin-3b

  Cat. No.:  DC8455  
Chemical Structure
675576-97-3
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More than 5000 active chemicals with high quality for research!
Field of application
Nutlin-3b is 150-fold less potent as an inhibitor of p53-MDM2 interaction than (?)-nutlin-3, demonstrating an IC50 value of 13.6 μM.
Cas No.: 675576-97-3
Synonyms: Nutlin-3b,nutlin 3b,nutlin3b,(+)Nutlin-3
SMILES: N1CCN(C(N2C(C3=CC=C(OC)C=C3OC(C)C)=N[C@@H](C3=CC=C(Cl)C=C3)[C@H]2C2=CC=C(Cl)C=C2)=O)CC1=O
Formula: C30H30Cl2N4O4
M.Wt: 581.49
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: (+)-Nutlin-3 is arbitrarily referred to as enantiomer b because it appears as the second peak from chiral purification of racemic nutlin-3 and its absolute stereocenter assignment is not known. It is 150-fold less potent as an inhibitor of p53-MDM2 interaction than (?)-nutlin-3, demonstrating an IC50 value of 13.6 μM. This inactive enantiomer can serve as a useful control for non-MDM2 related cellular activities. For the detailed information of Nutlin-3b, the solubility of Nutlin-3b in water, the solubility of Nutlin-3b in DMSO, the solubility of Nutlin-3b in PBS buffer, the animal experiment (test) of Nutlin-3b, the cell expriment (test) of Nutlin-3b, the in vivo, in vitro and clinical trial test of Nutlin-3b, the EC50, IC50,and affinity,of Nutlin-3b, For the detailed information of Nutlin-3b, the solubility of Nutlin-3b in water, the solubility of Nutlin-3b in DMSO, the solubility of Nutlin-3b in PBS buffer, the animal experiment (test) of Nutlin-3b, the cell expriment (test) of Nutlin-3b, the in vivo, in vitro and clinical trial test of Nutlin-3b, the EC50, IC50,and affinity,of Nutlin-3b, Please contact DC Chemicals.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
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DC8455 Nutlin-3b Nutlin-3b is 150-fold less potent as an inhibitor of p53-MDM2 interaction than (?)-nutlin-3, demonstrating an IC50 value of 13.6 μM.
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