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(R)-Baclofen hydrochloride

  Cat. No.:  DC23228   Featured
Chemical Structure
63701-55-3
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More than 5000 active chemicals with high quality for research!
Field of application
A derivative of the neurotransmitter GABA that acts as a GABAB receptor agonist.
Cas No.: 63701-55-3
Chemical Name: Benzenepropanoicacid, b-(aminomethyl)-4-chloro-, hydrochloride(1:1), (bR)-
Synonyms: Benzenepropanoicacid, b-(aminomethyl)-4-chloro-, hydrochloride(1:1), (bR)-;(3R)-4-amino-3-(4-chlorophenyl)butanoic acid,hydrochloride;R(+)-Baclofen . hydrochloride;R-(+)-Baclofen hydrochloride;Arbaclofen HCl;Arbaclofen hydrochloride;d-Baclofen hydrochloride;STX 209 hydrochloride;STX-209 hydrochloride;R(+)-BACLOFEN HYDROCHLORIDE
SMILES: Cl.OC(=O)C[C@@H](CN)C1=CC=C(Cl)C=C1
Formula: C10H12NO2Cl.HCl
M.Wt: 250.12172
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: (R)-Baclofen Hcl(STX-209 Hcl) is a derivative of gamma-aminobutyric acid (GABA) primarily used to treat spasticity and is in the early research stages for use for the treatment of alcoholism.Baclofen (brand names Kemstro, Lioresal, Liofen, Gablofen, Beklo and Baclosan) is a derivative of gamma-aminobutyric acid (GABA). It is primarily used to treat spasticity and is in the early research stages for use for the treatment of alcoholism. It is also used by compounding pharmacies in topical pain creams as a muscle relaxant.It is an agonist for the GABAB receptors. Its beneficial effects in spasticity result from actions at spinal and supraspinal sites. Baclofen can also be used to treat hiccups, and has been shown to prevent rises in body temperature induced by the drug MDMA in rats.In addition, research has shown baclofen to be effective in the treatment of alcohol dependence and withdrawal, by inhibiting both withdrawal symptoms andcravings.
Target: GABA
References: [1]. Mezler M, et al. Cloning and functional expression of GABA(B) receptors from Drosophila. Eur J Neurosci. 2001 Feb;13(3):477-86. [2]. Dzitoyeva S, et al. Gamma-aminobutyric acid B receptor 1 mediates behavior-impairing actions of alcohol in Drosophila: adult RNA interference and pharmacological evidence. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5485-90. Epub 2003 Apr 11.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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