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| Cas No.: | 6323-99-5 |
| Chemical Name: | DL-2-Amino-4-phosphonobutanoic acid (AP4) |
| Synonyms: | 2-amino-4-phosphonobutanoic acid;2-amino-4-phosphonobutyric acid;DL-2-Amino-4-phosphonobutanoic acid (AP4) |
| SMILES: | C(CP(=O)(O)O)C(C(=O)O)N |
| Formula: | C4H10NO5P |
| M.Wt: | 183.099662303925 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | DL-AP4 (2-Amino-4-phosphonobutyric acid) is a glutamate antagonist. DL-AP4 behaves as a competitive inhibitor of glutamate binding with an apparent Kd of 66 μM. DL-AP4 can be used for the research of central nervous system and visual system[1][2][3]. |
| In Vitro: | DL-AP4 (500 μM) reduces the tonic inward current by closing ion channels at holding potentials of -33 mV in isolated rod bipolar cells[1]. DL-AP4 (0.1 M; 1h) antagonizes the excitatory action of glutamate applied iontophoretically to receptors present in the locust muscle membrane[2]. DL-AP4 (compound 2) antagonizes excitatory synapses in the lateral perforant path of the rat hippocampal slice with an apparent Kd of 2.5 μM[3]. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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