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SB-657510

  Cat. No.:  DC7288   Featured
Chemical Structure
474960-44-6
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More than 5000 active chemicals with high quality for research!
Field of application
Selective urotensin-II (UT) receptor antagonist (Ki values are 61, 17, 30, 65 and 56 nM at human, monkey, cat, rat and mouse receptors respectively). Inhibits U-II-induced intracellular Ca2+ mobilization (IC50 = 180 nM) and antagonizes the contractile act
Cas No.: 474960-44-6
Chemical Name: Benzenesulfonamide, 2-bromo-N-[4-chloro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-dimethoxy-
Synonyms: Benzenesulfonamide, 2-bromo-N-[4-chloro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-dimethoxy-;2-BROMO-N-[4-CHLORO-3-[[(3R)-1-METHYL-3-PYRROLIDINYL]OXY]PHENYL]-4,5-DIMETHOXYBENZENESULFONAMIDE;SB 657510;2-Bromo-N-[4-chloro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-dimethoxy-benzenesulfonamide;CHEMBL2348501;KB-75257;SB-657510;SureCN5835362
SMILES: CN1CC[C@H](C1)OC2=C(C=CC(=C2)NS(=O)(=O)C3=CC(=C(C=C3Br)OC)OC)Cl
Formula: C19H22N2O5SclBr
M.Wt: 505.81038
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Selective urotensin-II (UT) receptor antagonist (Ki values are 61, 17, 30, 65 and 56 nM at human, monkey, cat, rat and mouse receptors respectively). Inhibits U-II-induced intracellular Ca2+mobilization (IC50 = 180 nM) and antagonizes the contractile action of U-II in isolated mammalian arteries and aortae (EC50 = 50 - 189 nM).For the detailed information of SB-657510, the solubility of SB-657510 in water, the solubility of SB-657510 in DMSO, the solubility of SB-657510 in PBS buffer, the animal experiment (test) of SB-657510, the cell expriment (test) of SB-657510, the in vivo, in vitro and clinical trial test of SB-657510, the EC50, IC50,and Affinity of SB-657510, Please contact DC Chemicals.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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