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P7C3

  Cat. No.:  DC7476   Featured
Chemical Structure
301353-96-8
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More than 5000 active chemicals with high quality for research!
Field of application
Proneurogenic, neuroprotective compound. Protects newborn neurons in the dentate gyrus and stimulates the growth of new neurons. Also enhances learning and memory in aged rats. Orally available and brain penetrant.
Cas No.: 301353-96-8
Chemical Name: 1-anilino-3-(3,6-dibromocarbazol-9-yl)propan-2-ol
Synonyms: P7C3, 301353-96-8
SMILES: C(N1C2=C(C=C(Br)C=C2)C2=C1C=CC(Br)=C2)C(O)CNC1=CC=CC=C1
Formula: C21H18Br2N2O
M.Wt: 474.18842
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: P7C3 is a NAMPT activator. P7C3 can enhance learning and memory in aged rats. Protects newborn neurons in the dentate gyrus by mitigating cell death.
In Vivo: P7C3 is orally bioavailable, crosses the blood-brain barrier, and is non-toxic at doses several fold higher than the efficacious dose.An easily administered pro-neurogenic compound. The administration of P7C3 is 10mg/ kg( IP) in rats. Administration of P7C3 to normal mice, as well as npas3-/- mice, enhance survival of neurons subsequent to their birth in the SGZ.
In Vitro: Administration of active P7C3 chemicals to cells treated with doxorubicin, which induces NAD depletion, led to a rebound in intracellular levels of NAD and concomitant protection from doxorubicin-mediated toxicity.
References: [1]. Pieper AA et al. Discovery of a proneurogenic, neuroprotective chemical. Cell. 2010 Jul 9;142(1):39-51. [2]. Wang G et al. P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage. Cell. 2014 Sep 11;158(6):1324-34. [3]. Pieper AA et al. P7C3 and an unbiased approach to drug discovery for neurodegenerative diseases. Chem Soc Rev. 2014 Oct 7;43(19):6716-26.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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