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Brassinazole

  Cat. No.:  DC32382   Featured
Chemical Structure
224047-41-0
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More than 5000 active chemicals with high quality for research!
Field of application
Brassinazole is an inhibitor of brassinosteroid biosynthesis that has been developed in order to probe the myriad functions of brassinosteroids.
Cas No.: 224047-41-0
Chemical Name: 4-(4-chlorophenyl)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)butan-2-ol
Synonyms: Brassinazole ,
SMILES: OC(C1=CC=CC=C1)(C)C(CC2=CC=C(Cl)C=C2)N3N=CN=C3
Formula: C18H18ClN3O
M.Wt: 327.81
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: [1]. Y K Min, et al. New Lead Compounds for Brassinosteroid Biosynthesis Inhibitors. Bioorg Med Chem Lett. 1999 Feb 8;9(3):425-30. [2]. Eriko Sasaki, et al. Uniconazole, a Cytochrome P450 Inhibitor, Inhibits Trans-Zeatin Biosynthesis in Arabidopsis. Phytochemistry. 2013 Mar;87:30-8.
Description: (Rac)-Brassinazole, triazole-type compound, is a brassinosteroid (BR) biosynthesis inhibitor. (Rac)-Brassinazole increases inhibition of CYP90B in BR biosynthesis[1][2]
In Vitro: (Rac)-Brassinazole (compound 5) does not retard rice stem elongation, and retardation is recovered by the addition of gibberellin (GA3), suggesting that such retardation is due to the inhibition of gibberellin biosynthesis[1]. (Rac)-Brassinazol (compound 31) results in a reduction in the effect on AtKO in gibberellin (GA) biosynthesis[2].
References: [1]. Y K Min, et al. New Lead Compounds for Brassinosteroid Biosynthesis Inhibitors. Bioorg Med Chem Lett. 1999 Feb 8;9(3):425-30. [2]. Eriko Sasaki, et al. Uniconazole, a Cytochrome P450 Inhibitor, Inhibits Trans-Zeatin Biosynthesis in Arabidopsis. Phytochemistry. 2013 Mar;87:30-8.
MSDS
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MSDS_14694_DC32382_224047-41-0
COA
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Cat. No. Product name Field of application
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DC74557 PREX-in1 PREX-in1 is a specific small-molecule inhibitor of P-Rex1 and P-Rex2 Rac-GEF activity with IC50 of 4.5 uM (P-Rex1 DHPH Rac-GEF activity) in liposome-based GEF assay, inhibits P-Rex1 and P-Rex2 through their catalytic DH domain.
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DC74225 YB-537 YB-537 (YB537) is a potent, highly specific quinone reductase 2 (QR2) inhibitor with IC50 of 3 nM, shows no activity against QR1 (IC50>10 uM).
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