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SC-26196

  Cat. No.:  DC7029   Featured
Chemical Structure
218136-59-5
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More than 5000 active chemicals with high quality for research!
Field of application
A selective Δ6 desaturase inhibitor that displays selectivity over Δ5 and Δ9 desaturases
Cas No.: 218136-59-5
Chemical Name: (E)-2,2-Diphenyl-5-(4-((pyridin-3-ylmethylene)amino)piperazin-1-yl)pentanenitrile
Synonyms: (E)-2,2-Diphenyl-5-(4-((pyridin-3-ylmethylene)amino)piperazin-1-yl)pentanenitrile;SC-26196;(E)-2,2-diphenyl-5-(4-(pyridin-3-ylmethyleneamino)piperazin-1-yl)pentanenitrile;SC 26196
SMILES: N#CC(C1=CC=CC=C1)(C2=CC=CC=C2)CCCN3CCN(/N=C/C4=CC=CN=C4)CC3
Formula: C27H29N5
M.Wt: 423.55266
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: SC-26196 is a potent, orally active Delta6 desaturase (D6D) inhibitor (IC50=0.2 μM in a rat liver microsomal assay). Antiinflammatory properties[1].
In Vivo: SC-26196 ( included in the diet at 0, 0.07, 0.21, or 0.7 mg/kg diet to achieve dosages of 0, 10, 30, and 100 mg/kg per day) causes a decrease in the calculated Δ6-desaturase index in both adipose tissue and liver. Feeding 100 mg SC-26196 per kg BW per day inhibits the Δ6-desaturase enzyme[3]. Animal Model: Male mice (12- or 15-week-old)[3] Dosage: 0, 10, 30, and 100 mg/kg per day Administration: Included in the diet at 0, 0.07, 0.21, or 0.7mg/kg diet to achieve dosages of 0, 10, 30, and 100mg/kg per day. Result: Caused a decrease in the calculated Δ6-desaturase index in both adipose tissue and liver.
In Vitro: IC50: 0.2 μM (Delta6 desaturase in a rat liver microsomal assay)[1]
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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