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Vorasidenib (AG881)

  Cat. No.:  DC10439   Featured
Chemical Structure
1644545-52-7
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More than 5000 active chemicals with high quality for research!
Field of application
AG-881 is a potent and selective orally available inhibitor of mutated forms of both isocitrate dehydrogenase type 1 (IDH1) in the cytoplasm and type 2 (IDH2).
Cas No.: 1644545-52-7
Chemical Name: Vorasidenib
Synonyms: Vorasidenib;AG881;789Q85GA8P;6-(6-chloropyridin-2-yl)-N2,N4-bis((R)-1,1,1-trifluoropropan-2-yl)-1,3,5-triazine-2,4-diamine;6-(6-chloropyridin-2-yl)-N2,N4-bis[(2R)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine;9UO;Vorasidenib [INN];Vorasidenib [USAN];Vorasidenib (AG881);Vorasidenib (USAN/INN);AG 881 [WHO-DD];GTPL10663;BDBM279948;NSC803600;s8611;US10028961, C
SMILES: ClC1=C([H])C([H])=C([H])C(C2=NC(=NC(=N2)N([H])[C@]([H])(C([H])([H])[H])C(F)(F)F)N([H])[C@]([H])(C([H])([H])[H])C(F)(F)F)=N1
Formula: C14H13ClF6N6
M.Wt: 414.7366
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Vorasidenib is a pan isocitrate dehydrogenase (IDH) inhibitor.
In Vitro: Vorasidenib has recently entered phase 1 clinical trials in hematologic (NCT02492737) and solid malignancies (NCT02481154) in patients with either an IDH1 or an IDH2 mutation. Preclinical studies have suggested that Vorasidenib fully penetrates the blood-brain barrier and may be a more effective option for patients with IDH1/2 mutated glioma[1].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC10439 Vorasidenib (AG881) AG-881 is a potent and selective orally available inhibitor of mutated forms of both isocitrate dehydrogenase type 1 (IDH1) in the cytoplasm and type 2 (IDH2).
DC8374 AG-221(Enasidenib) AG-221 is an orally available, selective, potent inhibitor of the mutated IDH2 protein.
DC8051 AG-120 (Ivosidenib) AG-120 is a first-in-class, orally available, selective, potent inhibitor of the mutated IDH1 protein.
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