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Z-VAD(OH)-FMK

  Cat. No.:  DC8639   Featured
Chemical Structure
161401-82-7
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More than 5000 active chemicals with high quality for research!
Field of application
Z-VAD(OH)-FMK is an irreversible tripeptide inhibitor of all caspases.
Cas No.: 161401-82-7
Chemical Name: L-Alaninamide,N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-1-(carboxymethyl)-3-fluoro-2-oxopropyl]-
SMILES: FCC(=O)C(CC(O)=O)NC(=O)C(C)NC(=O)C(C(C)C)NC(=O)OCC1=CC=CC=C1
Formula: C21H28N3O7F
M.Wt: 453.46132
Purity: >99%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Z-VAD-FMK (Z-VAD(OH)-FMK) is a well-know pan caspase inhibitor, which does not inhibit ubiquitin carboxy-terminal hydrolase L1 (UCHL1) activity even at concentrations as high as 440 μM[1].
Target: Caspase
In Vitro: Z-VAD-FMK (40 μM) reverses the apoptotic effect exerted by total saponin of Solanum lyratum Thunb (TSSLT) in Hela cells. HeLa cells are pretreated with Z-VAD-FMK (40 μM) for 30 min and exposed to TSSLT (6 μg/mL) for 48 h[2]. Cell Viability Assay[2] Cell Line: HeLa cells Concentration: 40 μM Incubation Time: Prtreated for 30 minutes Result: Prevented TSSLT-induced cell death. More than 80% cell survival was observed.
References: [1]. Davies CW, et al. The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK). Bioorg Med Chem Lett. 2012 Jun 15;22(12):3900-4. [2]. Liu HR, et al. Antiproliferative activity of the total saponin of Solanum lyratum Thunb in Hela cells by inducing apoptosis. Pharmazie. 2008 Nov;63(11):836-42.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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