成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Alternate TextTo enhance service speed and avoid tariff delays, we've opened a US warehouse. All US orders ship directly from our US facility.

Bictegravir

  Cat. No.:  DC10890   Featured
Chemical Structure
1611493-60-7
For research use only. We do not sell to patients.
We match the best price and quality on market.
Email:order@dcchemicals.com  sales@dcchemicals.com
Tel:+86-021-58447131
We are official vendor of:
  • 20
  • 19
  • 18
  • 17
  • 16
  • 15
  • 14
  • 12
  • 11
  • 10
  • 9
  • 8
  • 13
  • 6
  • 5
  • 4
  • 3
  • 2
  • 1
More than 5000 active chemicals with high quality for research!
Field of application
Bictegravir is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.
Cas No.: 1611493-60-7
Chemical Name: Bictegravir
Synonyms: Bictegravir;8GB79LOJ07;Bictegravir [INN];Bictegravir [USAN:INN];GS 9883;Bictegravir (USAN/INN);BDBM330048;BCP25703;s5911;DB11799;SB18851
SMILES: FC1C([H])=C(C([H])=C(C=1C([H])([H])N([H])C(C1C(C(=C2C(N3[C@@]([H])(C([H])([H])N2C=1[H])O[C@]1([H])C([H])([H])C([H])([H])[C@@]3([H])C1([H])[H])=O)O[H])=O)=O)F)F
Formula: C21H18F3N3O5
M.Wt: 449.3799
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Bictegravir is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.
In Vitro: Bictegravir (BIC) inhibits the strand transfer activity with an IC50 of 7.5± 0.3 nM. Relative to its inhibition of strand transfer activity, Bictegravir is a much weaker inhibitor of 3′-processing activity of HIV-1 IN, with an IC50 of 241±51 nM. Bictegravir enhances the accumulation of 2-LTR circles ~5-fold relative to the mock-treated control and reduces the amount of authentic integration products in infected cells by 100-fold. Bictegravir potently inhibits HIV-1 replication in both MT-2 and MT-4 cells with EC50s of 1.5 and 2.4 nM, respectively. Bictegravir exhibits potent antiviral effects in both primary CD4+ T lymphocytes and monocyte-derived macrophages, with EC50s of 1.5±0.3 nM and 6.6±4.1 nM, respectively, which are comparable to values obtained in T-cell lines[1].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC11397 TAK-779 TAK-779 is a potent and selective nonpeptide antagonist of CCR5 and CXCR3, with a Ki of 1.1 nM for CCR5, and effectively and selectively inhibits R5 HIV-1, with EC50 and EC90 of 1.2 nM and 5.7 nM, respectively, in MAGI-CCR5 cells.
DC7266 Rilpivirine(R 278474, TMC 278) Rilpivirine(R 278474, TMC 278) is a type of anti-HIV medicine called a non-nucleoside reverse transcriptase inhibitor (NNRTI).
DC5902 Emtricitabine Emtricitabine is a nucleoside analogue which inhibits the reverse nucleoside transcriptase enzyme. Structurally this antiviral agent is similar to Lamivudine. This agent is effective at targeting HIV and HBV viruses since these viruses replicate in a reve
DC10250 Dolutegravir Sodium Dolutegravir is a HIV integrase inhibitor with IC50 of 2.7 nM.
DC7273 Dolutegravir Dolutegravir (DTG, GSK1349572) is an integrase inhibitor(IC50= 2.7 nM), modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H.
DC9700 BMS-707035 BMS-707035 is a potent, specific, and reversible HIV-I integrase (IN) inhibitor that blocks HIV IN strand transfer activity.
DC10890 Bictegravir Bictegravir is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.
DC3150 Atazanavir Atazanavir is a HIV protease inhibitor with Ki of 2.66 nM.
X