DC11689 |
RU-301
|
RU-301 (RU301) is a small molecule pan-TAM inhibitor that targets the TAM Ig1-Gas6 interface, blocks Gas6-dependent TAM activation. |
DC10127 |
UNC569
|
UNC569 is a novel small-molecule MER inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo. |
DC7931 |
UNC2025
|
UNC2025 is a potent and orally bioavailable Mer/Flt3 dual inhibitor with IC50 of 0.8/0.74 nM for Mer/Flt3. |
DC9289 |
UNC-2025 HCl
|
UNC-2025 is a potent and orally bioavailable dual MER/FLT3 inhibitor with IC50 of 0.74 nM and 0.8 nM, respectively, about 20-fold selectivity over Axl and Tyro3. |
DC8223 |
TP-0903
|
TP-0903 is a a high-affinity Axl inhibitor with IC50 of 27 nM. |
DC8535 |
SGI-7079
|
SGI-7079 is a novel Axl inhibitor. |
DC10071 |
S49076
|
S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 values below 20 nM. |
DC11265 |
S49076 (hydrochloride)
|
S49076 is a novel kinase inhibitor of MET, AXL, and FGFR with strong preclinical activity alone and in association with bevacizumab. |