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Tazarotenic acid (AGN 190299)

  Cat. No.:  DC7619   Featured
Chemical Structure
118292-41-4
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More than 5000 active chemicals with high quality for research!
Field of application
Tazarotenic Acid is an agent that acts as the principle active metabolite
Cas No.: 118292-41-4
Chemical Name: 6-[2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylic acid
Synonyms: Tazarotenic acid, 118292-41-4, 6-(2-(4,4-Dimethylthiochroman-6-yl)ethynyl)nicotinic acid
SMILES: O=C(O)C1=CN=C(C#CC2=CC=C3C(C(C)(C)CCS3)=C2)C=C1
Formula: C19H17NO2S
M.Wt: 323.40878
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma[1][2][3].
In Vivo: Assessment of Pharmacokinetics (PK) profile of Tazarotenic acid (Compound AGN 190299) after an intravenous of AGN 190168 in rats[1] . Male Female Male Dose (mg kg-1) 4.4 4.4 0.49 AUC (μg h mL-1) 9.31 (2.14) 9.78 (1.36) 0.594 (0.95) CL (mL min-1 kg-1) 7.96 (1.59) 7.62 (0.85) 14.0 (2.2) k (h-1) 0.562 (0.339) 0.820 (0.146) 0.741 (0.115) T1/2 (h) 1.64 (0.92) 0.86 (0.14) 0.95 (0.16) V0 (L kg-1) 0.43 (0.05) 0.49 (0.06) 1.31 (1.15) Vβ (L kg-1) - - 1.14 (0.09) Vmax (μg min-1) 9.08 (2.89) 6.09 (1.22) - Km (μg mL-1) 7.09 (1.35) 5.12 (1.19) -
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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