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Sarecycline(P005672 hydrochloride)

  Cat. No.:  DC5188   Featured
Chemical Structure
1035979-44-2
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More than 5000 active chemicals with high quality for research!
Field of application
P005672 is a phase II drug for antibacterial/anti-inflammatory acne treatment.
Cas No.: 1035979-44-2
Chemical Name: (4S,4aS,5aR,12aS)-4-(dimethylamino)-3,10,12,12a-tetrahydroxy-7-((methoxy(methyl)amino)methyl)-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride
Synonyms: WC-3035; WC 3035; WC3035; P005672; P-005672; P 005672; P005672 HCl; Sarecycline hydrochloride; Seysara
SMILES: CN(OC)CC1=C2C(C(C3=C(O)[C@@](C(C(C(N)=O)=C(O)[C@H]4N(C)C)=O)(O)[C@@]4([H])C([H])[C@]3([H])C2)=O)=C(O)C=C1.Cl
Formula: C24H30ClN3O8
M.Wt: 523.967
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Sarecycline hydrochloride is a narrow-spectrum tetracycline-class antibiotic. Sarecycline hydrochloride possesses anti-inflammatory properties and potent activity against Gram-positive bacteria, including activity against multiple strains of Cutibacterium acnes. Sarecycline hydrochloride interferes with tRNA accommodation and tethers mRNA to the 70S ribosome[1][2][3].
In Vivo: Sarecycline hydrochloride (0.33-9?mg/kg; i.v.) show potent activity against S. aureus in a murine neutropenic thigh infection model[1]. Animal Model: Female SD-1 mice (A murine neutropenic thigh wound infection model)[1] Dosage: 0.33, 1, 3, or 9?mg/kg Administration: Intravenously Result: Achieved a 2-log10 reduction in the bacterial burden in the thigh at a dose comparable to that of doxycycline, with ED50s of 8.23 and 8.32?mg/kg, respectively.
In Vitro: Sarecycline inhibits 55 clinical isolates of C. acnes, and the MIC values for Sarecycline ranged from 0.5 to 16?μg/ml; the MIC50 was 0.5 μg/ml, and the MIC90 was 4?μg/ml. Sarecycline, exhibits activity against the macrolide-resistant organisms[1]. Sarecycline hydrochloride exhibits minimal activity against enteric aerobic Gram-negative bacteria[2].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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