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Microcystin-LR

  Cat. No.:  DC23910  
Chemical Structure
101043-37-2
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More than 5000 active chemicals with high quality for research!
Field of application
A potent, selective inhibitor of protein phosphatase 2A (PP2A) with IC50 of 0.04 nM.
Cas No.: 101043-37-2
Chemical Name: Cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-(3S)-3-methyl-D-β-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl]
Synonyms: Cyanoginosin-LR;MC-LR
SMILES: O=C1[C@@H](C)[C@]([H])(/C=C/C(/C)=C/[C@H](C)[C@H](CC2C=CC=CC=2)OC)NC([C@H](CCCNC(N)=N)NC([C@@H](C)[C@H](C(O)=O)NC([C@H](CC(C)C)NC([C@@H](C)NC(C(=C)N(C)C(CC[C@H](C(O)=O)N1)=O)=O)=O)=O)=O)=O
Formula: C49H74N10O12
M.Wt: 995.1716
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: A potent, selective inhibitor of protein phosphatase 2A (PP2A) with IC50 of 0.04 nM; completely inhibits PP2A without affecting PP1 when used at a concentration of 0.5 nM, at least 10 times more potent as serine/threonine PP inhibitors than okadaic acid; PP1 IC50 is about 1.7 nM; shows cytotoxic activity against pancreatic cancer cells; also induces MMP-13 expression, promotes colorectal cancer invasion and migration.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC47250 Nonanal Nonanal is a saturated fatty aldehyde with antidiarrhoeal activity.
DC47249 Piperitone Piperitone is as a powerful repellent and antiappetent agent. Piperitone is very toxic to Cymbopogon schoenanthus (C. schoenanthus) adults, newly laid eggs and to neonate larvae. Insecticidal activity.
DC47247 Tyrosylleucine TFA Tyrosylleucine (Tyr-Leu, YL) TFA, an orally active dipeptide, exhibits a potent antidepressant-like activity.
DC47243 Dehydroglyasperin C Dehydroglyasperin C, a isoflavone, is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C has antioxidant, neuroprotective, cancer chemopreventive, and anti-inflammatory activities.
DC47227 (?)-Myrtenal (?)-Myrtenal ((1R)-(?)-Myrtenal) is an orally active terpene with antitumour activity. (?)-Myrtenal ameliorates hyperglycemia by enhancing GLUT2 through Akt in the skeletal muscle and liver of diabetic rats.
DC47224 GPX4-IN-3 GPX4-IN-3 (26a) is a potent glutathione peroxidase 4 (GPX4) inhibitor as a selective ferroptosis inducer. GPX4-IN-3 (26a) exhibits 71.7% inhibition for GPX4 with 1 μM.
DC47179 Tyrosylleucine Tyrosylleucine (Tyr-Leu, YL), an orally active dipeptide, exhibits a potent antidepressant-like activity.
DC47178 Mead acid Mead acid (5,8,11-Eicosatrienoic acid), an unsaturated (Omega-9) fatty acid, is an indicator of essential fatty acid deficiency.
DC47140 Yadanzioside K Yadanzioside K is a natural quassinoid glucoside found in Brucea amarissima.
DC47105 Complanatoside B Complanatoside B is a?P. chinense?Fisch flavonoid with potential anti-inflammatory effects.
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