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  2. Metabolic Enzyme/Protease Neuronal Signaling Membrane Transporter/Ion Channel
  3. Endogenous Metabolite GABA Receptor
  4. p-Hydroxybenzaldehyde

p-Hydroxybenzaldehyde  (Synonyms: 對(duì)羥基苯甲醛)

目錄號(hào): HY-Y0313 純度: 99.98%
COA 產(chǎn)品使用指南 技術(shù)支持

p-Hydroxybenzaldehyde 是香草的主要成分之一，在高濃度下對(duì) α1β2γ2S GABAA receptor 受體具有拮抗作用。

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p-Hydroxybenzaldehyde Chemical Structure

p-Hydroxybenzaldehyde Chemical Structure

CAS No. : 123-08-0

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥220
In-stock
1 g ￥200
In-stock
5 g ￥450
In-stock
10 g   詢價(jià)  
50 g   詢價(jià)  

* Please select Quantity before adding items.

Customer Review

Other Forms of p-Hydroxybenzaldehyde:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

p-Hydroxybenzaldehyde is a one of the major components in vanilla aroma, with antagonistic effect on GABAA receptor of the α1β2γ2S subtype at high concentrations.

IC50 & Target

GABA Receptor[1]
細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 10 μM
Compound: 23
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
[PMID: 25710081]
A549 GI50
> 100 μM
Compound: 1
Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay
[PMID: 25752525]
HBL-100 GI50
> 100 μM
Compound: 1
Antiproliferative activity against human HBL100 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human HBL100 cells after 48 hrs by sulforhodamine B assay
[PMID: 25752525]
HeLa GI50
> 100 μM
Compound: 1
Antiproliferative activity against human HeLa cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human HeLa cells after 48 hrs by sulforhodamine B assay
[PMID: 25752525]
HT-1080 ED50
> 100 μM
Compound: 19
Antiproliferative activity against human HT1080 cells by MTT assay
Antiproliferative activity against human HT1080 cells by MTT assay
[PMID: 11277741]
HT-22 EC50
33.2 μM
Compound: 33
Neuroprotective activity against glutamate-induced cell death in mouse HT-22 cells assessed as increase in cell viability after 24 hrs by EZ-Cytox assay
Neuroprotective activity against glutamate-induced cell death in mouse HT-22 cells assessed as increase in cell viability after 24 hrs by EZ-Cytox assay
[PMID: 32991171]
HUVEC GI50
> 100 μM
Compound: 18
Antiproliferative activity against HUVEC assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay
Antiproliferative activity against HUVEC assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay
[PMID: 30951308]
K562 IC50
> 10 μM
Compound: 23
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
[PMID: 25710081]
Neutrophil IC50
> 10 μM
Compound: 42
Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/cytochalasin B-induced superoxide anion generation by measuring superoxide dismutase-inhibitable reduction of ferricytochrome c preincubated for 5 mins followed by FMLP/cytochal
Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/cytochalasin B-induced superoxide anion generation by measuring superoxide dismutase-inhibitable reduction of ferricytochrome c preincubated for 5 mins followed by FMLP/cytochal
[PMID: 27525452]
Neutrophil IC50
3.3 μM
Compound: 42
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as elastase substrate preincubated for 5 mins followed by fMLP/CB-induction
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as elastase substrate preincubated for 5 mins followed by fMLP/CB-induction
[PMID: 27525452]
RAW264.7 IC50
> 50 μM
Compound: 33
Antiinflammatory activity in mouse RAW264.7 assessed as inhibition of LPS-induced NO production preincubated for 30 mins followed by LPS stimulation measured after 24 hrs by Griess reagent based assay
Antiinflammatory activity in mouse RAW264.7 assessed as inhibition of LPS-induced NO production preincubated for 30 mins followed by LPS stimulation measured after 24 hrs by Griess reagent based assay
[PMID: 33939429]
SH-SY5Y EC50
30.2 μM
Compound: 27
Neuroprotective activity in human SH-SY5Y cells assessed as reduction in 6-OHDA-induced cell death measured after 24 hrs by MTT assay
Neuroprotective activity in human SH-SY5Y cells assessed as reduction in 6-OHDA-induced cell death measured after 24 hrs by MTT assay
[PMID: 27420919]
SW1573 GI50
> 100 μM
Compound: 1
Antiproliferative activity against human SW1573 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human SW1573 cells after 48 hrs by sulforhodamine B assay
[PMID: 25752525]
T47D GI50
> 100 μM
Compound: 1
Antiproliferative activity against human T47D cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human T47D cells after 48 hrs by sulforhodamine B assay
[PMID: 25752525]
WiDr GI50
> 100 μM
Compound: 1
Antiproliferative activity against human WiDr cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human WiDr cells after 48 hrs by sulforhodamine B assay
[PMID: 25752525]
Y79 GI50
> 100 μM
Compound: 18
Cytotoxicity against human Y79 cells assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay
Cytotoxicity against human Y79 cells assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay
[PMID: 30951308]
體外研究
(In Vitro)

p-Hydroxybenzaldehyde (4-hydroxybenzaldehyde) 是竹筍中的主要成分之一，對(duì) α1β 的 GABAA 受體具有拮抗作用高濃度下的 2γ2S 亞型。p-Hydroxybenzaldehyde (101.7 μM) 顯著降低非洲爪蟾卵母細(xì)胞上表達(dá)的 GABAA 受體的 GABA 誘導(dǎo)的氯化物電流[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

122.12

Formula

C7H6O2
CAS 號(hào)
性狀

固體

顏色

Off-white to yellow

中文名稱

對(duì)羥基苯甲醛
結(jié)構(gòu)分類
初始來(lái)源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 100 mg/mL (818.85 mM; 超聲助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開封的 DMSO)

H2O 中的溶解度 : 10 mg/mL (81.88 mM; 超聲助溶)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 8.1885 mL 40.9423 mL 81.8847 mL
5 mM 1.6377 mL 8.1885 mL 16.3769 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

* 備注：如您選擇水作為儲(chǔ)備液，請(qǐng)稀釋至工作液后，再用 0.22 μm 的濾膜過(guò)濾除菌后使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物實(shí)驗(yàn)：

請(qǐng)根據(jù)您的 實(shí)驗(yàn)動(dòng)物和給藥方式 選擇適當(dāng)?shù)娜芙夥桨浮?

以下溶解方案都請(qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液，再依次添加助溶劑：
——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；
以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的方式助溶

  • 方案 一

    請(qǐng)依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (20.47 mM); 澄清溶液

    此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。

    以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 400 μL PEG300 中，混合均勻；再向上述體系中加入 50 μL Tween-80，混合均勻；然后再繼續(xù)加入 450 μL 生理鹽水 定容至 1 mL。

    生理鹽水的配制：將 0.9 g 氯化鈉，溶解于 ddH?O 并定容至 100 mL，可以得到澄清透明的生理鹽水溶液。
  • 方案 二

    請(qǐng)依序添加每種溶劑： 10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (20.47 mM); 澄清溶液

    此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。

    以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 900 μL 20% 的 SBE-β-CD 生理鹽水水溶液 中，混合均勻。

    2 g SBE-β-CD（磺丁基醚 β-環(huán)糊精）粉末定容于 10 mL 的生理鹽水中，完全溶解至澄清透明。

以下溶解方案，請(qǐng)直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內(nèi)盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比； 如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的方式助溶。

  • 方案 一

    請(qǐng)依序添加每種溶劑： PBS

    Solubility: 14.29 mg/mL (117.01 mM); 澄清溶液; 超聲助溶

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
請(qǐng)輸入您的動(dòng)物體內(nèi)配方組成：
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
如果您的動(dòng)物是免疫缺陷鼠或者體弱鼠，建議 DMSO 中的在最后工作液體系中的占比盡量不超過(guò) 2%。
方案所需 助溶劑 包括：DMSO， ，均可在 MCE 網(wǎng)站選購(gòu)。 ，Tween 80，均可在 MCE 網(wǎng)站選購(gòu)。
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
儲(chǔ)備液配制方法 : mg 藥物溶于 μL  DMSO（母液濃度為 mg/mL）。

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

您所需的儲(chǔ)備液濃度超過(guò)該產(chǎn)品的實(shí)測(cè)溶解度，以下方案僅供參考，如有需要，請(qǐng)與 MCE 中國(guó)技術(shù)支持聯(lián)系。
動(dòng)物實(shí)驗(yàn)體內(nèi)工作液的配制方法 : 取 μL DMSO 儲(chǔ)備液，加入 μL 。 μL ，混合均勻至澄清，再加 μL Tween 80，混合均勻至澄清，再加 μL 生理鹽水。
連續(xù)給藥周期超過(guò)半月以上，請(qǐng)謹(jǐn)慎選擇該方案。
請(qǐng)確保第一步儲(chǔ)備液溶解至澄清狀態(tài)，從左到右依次添加助溶劑。您可采用超聲加熱 （超聲清洗儀，建議頻次 20-40 kHz），渦旋吹打等方式輔助溶解。
純度 & 產(chǎn)品資料

純度: 99.98%

參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 8.1885 mL 40.9423 mL 81.8847 mL 204.7116 mL
5 mM 1.6377 mL 8.1885 mL 16.3769 mL 40.9423 mL
10 mM 0.8188 mL 4.0942 mL 8.1885 mL 20.4712 mL
15 mM 0.5459 mL 2.7295 mL 5.4590 mL 13.6474 mL
20 mM 0.4094 mL 2.0471 mL 4.0942 mL 10.2356 mL
25 mM 0.3275 mL 1.6377 mL 3.2754 mL 8.1885 mL
30 mM 0.2729 mL 1.3647 mL 2.7295 mL 6.8237 mL
40 mM 0.2047 mL 1.0236 mL 2.0471 mL 5.1178 mL
50 mM 0.1638 mL 0.8188 mL 1.6377 mL 4.0942 mL
60 mM 0.1365 mL 0.6824 mL 1.3647 mL 3.4119 mL
80 mM 0.1024 mL 0.5118 mL 1.0236 mL 2.5589 mL
DMSO 100 mM 0.0819 mL 0.4094 mL 0.8188 mL 2.0471 mL

* 備注：如您選擇水作為儲(chǔ)備液，請(qǐng)稀釋至工作液后，再用 0.22 μm 的濾膜過(guò)濾除菌后使用。

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產(chǎn)品名稱：
p-Hydroxybenzaldehyde
目錄號(hào)：
HY-Y0313
需求量：