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  2. Anti-infection
  3. HIV
  4. 2',3'-Dideoxyadenosine

2',3'-Dideoxyadenosine  (Synonyms: 2',3'-二脫氧腺苷)

目錄號(hào): HY-W013441 純度: 99.89%
COA 產(chǎn)品使用指南

2',3'-Dideoxyadenosine 是 HIV 復(fù)制抑制劑。抗逆轉(zhuǎn)錄病毒活性?？共《净钚?sup> [1]。

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2',3'-Dideoxyadenosine Chemical Structure

2',3'-Dideoxyadenosine Chemical Structure

CAS No. : 4097-22-7

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規(guī)格 價(jià)格 是否有貨 數(shù)量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥598
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5 mg ￥500
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10 mg ￥800
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25 mg ￥1350
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50 mg ￥2038
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100 mg ￥3038
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200 mg   詢價(jià)  
500 mg   詢價(jià)  

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Customer Review

Other Forms of 2',3'-Dideoxyadenosine:

MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻(xiàn)

查看 HIV 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

2',3'-Dideoxyadenosine is an inhibitor of HIV replication[1]. Antiretroviral activity[1]. Antiviral efficacy[1].

IC50 & Target

HIV-1

 

HIV-2

 

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
CCRF-CEM IC50
> 250 μM
Compound: 3, ddA
Cytostatic activity against human CEM cells assessed as growth inhibition after 3 days by particle counting analysis
Cytostatic activity against human CEM cells assessed as growth inhibition after 3 days by particle counting analysis
[PMID: 24177359]
CCRF-CEM EC50
2.8 μM
Compound: 3, ddA
Antiviral activity against HIV2 ROD infected in human CEM cells assessed as virus-induced giant cell formation after 4 days by microscopic analysis
Antiviral activity against HIV2 ROD infected in human CEM cells assessed as virus-induced giant cell formation after 4 days by microscopic analysis
[PMID: 24177359]
CCRF-CEM EC50
7.2 μM
Compound: 3, ddA
Antiviral activity against HIV1 3B infected in human CEM cells assessed as virus-induced giant cell formation after 4 days by microscopic analysis
Antiviral activity against HIV1 3B infected in human CEM cells assessed as virus-induced giant cell formation after 4 days by microscopic analysis
[PMID: 24177359]
CEM-SS CC50
> 110 μM
Compound: ddA
Cytotoxicity against human CEM-SS cells assessed as reduction in cell viability incubated for 5 days by MTT assay
Cytotoxicity against human CEM-SS cells assessed as reduction in cell viability incubated for 5 days by MTT assay
[PMID: 33711763]
HeLa IC50
> 250 μM
Compound: 3, ddA
Cytostatic activity against human HeLa cells assessed as growth inhibition after 3 days by particle counting analysis
Cytostatic activity against human HeLa cells assessed as growth inhibition after 3 days by particle counting analysis
[PMID: 24177359]
L1210 IC50
> 250 μM
Compound: 3, ddA
Cytostatic activity against mouse L1210 cells assessed as growth inhibition after 2 days by particle counting analysis
Cytostatic activity against mouse L1210 cells assessed as growth inhibition after 2 days by particle counting analysis
[PMID: 24177359]
MT4 CC50
> 100 μM
Compound: ddA
Cytotoxicity against human MT4 cells after 96 hrs by MTT assay
Cytotoxicity against human MT4 cells after 96 hrs by MTT assay
[PMID: 19282192]
MT4 CC50
> 100 μM
Compound: D4A
Concentration required to reduce the number of viable uninfected MT-4 cells by 50%.
Concentration required to reduce the number of viable uninfected MT-4 cells by 50%.
[PMID: 1495007]
MT4 CC50
> 110 μM
Compound: ddA
Cytotoxicity against human MT4 cells assessed as reduction in cell viability incubated for 5 days by MTT assay
Cytotoxicity against human MT4 cells assessed as reduction in cell viability incubated for 5 days by MTT assay
[PMID: 33711763]
MT4 EC50
5.2 μM
Compound: ddA
Antiviral activity against HIV1 3B infected in human MT4 cells assessed as protection from virus-induced cytopathogenicity after 4 days by MTT assay
Antiviral activity against HIV1 3B infected in human MT4 cells assessed as protection from virus-induced cytopathogenicity after 4 days by MTT assay
[PMID: 19282192]
MT4 CC50
890 μM
Compound: ddAdo
Cytotoxic concentration of compound required to reduce the viability of mock-infected MT-4 cells by 50%
Cytotoxic concentration of compound required to reduce the viability of mock-infected MT-4 cells by 50%
[PMID: 2479745]
MT4 CC50
890 μM
Compound: DDA
Cytotoxic concentration required to reduce the viability of mock-infected MT-4 cells by 50%
Cytotoxic concentration required to reduce the viability of mock-infected MT-4 cells by 50%
[PMID: 1992136]
體外研究
(In Vitro)

2',3'-Dideoxyadenosine 抑制 MT-4 細(xì)胞中的 HIV-1 和猿猴免疫缺陷病毒 (SIV)，EC50 分別為 5.27 和 5.3 μM。2',3'-Dideoxyadenosine 抑制人 T 淋巴細(xì)胞 CEM 細(xì)胞中的 HIV-1 和 HIV-2，EC50 分別為 4 μM 和 8 μM。2',3'-Dideoxyadenosine 抑制 Molt 4/C8 細(xì)胞中的 HIV-1 和 HIV-2，EC50 分別為 4 μM 和 5.5 μM。2',3'-Dideoxyadenosine 抑制 C8166 細(xì)胞中的 HIV-1 和 HIV-2，EC50 分別為 17 μM 和 22 μM。2',3'-Dideoxyadenosine 抑制 C3H/3T3 細(xì)胞中的鼠肉瘤病毒 (MSV)，EC50 為 24 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

235.24

Formula

C10H13N5O2
CAS 號(hào)
性狀

固體

顏色

White to off-white

中文名稱

2',3'-二脫氧腺苷
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

H2O 中的溶解度 : 100 mg/mL (425.10 mM; 超聲助溶)

DMSO 中的溶解度 : 100 mg/mL (425.10 mM; 超聲助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開(kāi)封的 DMSO)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 4.2510 mL 21.2549 mL 42.5098 mL
5 mM 0.8502 mL 4.2510 mL 8.5020 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

* 備注：如您選擇水作為儲(chǔ)備液，請(qǐng)稀釋至工作液后，再用 0.22 μm 的濾膜過(guò)濾除菌后使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物實(shí)驗(yàn)：

請(qǐng)根據(jù)您的 實(shí)驗(yàn)動(dòng)物和給藥方式 選擇適當(dāng)?shù)娜芙夥桨浮?

以下溶解方案都請(qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液，再依次添加助溶劑：
——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；
以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的方式助溶

  • 方案 一

    請(qǐng)依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (8.84 mM); 澄清溶液

    此方案可獲得 ≥ 2.08 mg/mL（飽和度未知）的澄清溶液。

    以 1 mL 工作液為例，取 100 μL 20.8 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 400 μL PEG300 中，混合均勻；再向上述體系中加入 50 μL Tween-80，混合均勻；然后再繼續(xù)加入 450 μL 生理鹽水 定容至 1 mL。

    生理鹽水的配制：將 0.9 g 氯化鈉，溶解于 ddH?O 并定容至 100 mL，可以得到澄清透明的生理鹽水溶液。
  • 方案 二

    請(qǐng)依序添加每種溶劑： 10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (8.84 mM); 澄清溶液

    此方案可獲得 ≥ 2.08 mg/mL（飽和度未知）的澄清溶液。

    以 1 mL 工作液為例，取 100 μL 20.8 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 900 μL 20% 的 SBE-β-CD 生理鹽水水溶液 中，混合均勻。

    2 g SBE-β-CD（磺丁基醚 β-環(huán)糊精）粉末定容于 10 mL 的生理鹽水中，完全溶解至澄清透明。

以下溶解方案，請(qǐng)直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內(nèi)盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比； 如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的方式助溶。

  • 方案 一

    請(qǐng)依序添加每種溶劑： PBS

    Solubility: 14.29 mg/mL (60.75 mM); 澄清溶液; 超聲助溶 (<60°C)

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
該產(chǎn)品水溶性佳，請(qǐng)具體參考實(shí)測(cè) 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
您所需的儲(chǔ)備液濃度超過(guò)該產(chǎn)品的實(shí)測(cè)溶解度，如有需要，請(qǐng)與 MCE 中國(guó)技術(shù)支持聯(lián)系。
純度 & 產(chǎn)品資料

純度: 99.89%

參考文獻(xiàn)

2',3'-Dideoxyadenosine 相關(guān)分類

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 4.2510 mL 21.2549 mL 42.5098 mL 106.2744 mL
5 mM 0.8502 mL 4.2510 mL 8.5020 mL 21.2549 mL
10 mM 0.4251 mL 2.1255 mL 4.2510 mL 10.6274 mL
15 mM 0.2834 mL 1.4170 mL 2.8340 mL 7.0850 mL
20 mM 0.2125 mL 1.0627 mL 2.1255 mL 5.3137 mL
25 mM 0.1700 mL 0.8502 mL 1.7004 mL 4.2510 mL
30 mM 0.1417 mL 0.7085 mL 1.4170 mL 3.5425 mL
40 mM 0.1063 mL 0.5314 mL 1.0627 mL 2.6569 mL
50 mM 0.0850 mL 0.4251 mL 0.8502 mL 2.1255 mL
60 mM 0.0708 mL 0.3542 mL 0.7085 mL 1.7712 mL
80 mM 0.0531 mL 0.2657 mL 0.5314 mL 1.3284 mL
100 mM 0.0425 mL 0.2125 mL 0.4251 mL 1.0627 mL

* 備注：如您選擇水作為儲(chǔ)備液，請(qǐng)稀釋至工作液后，再用 0.22 μm 的濾膜過(guò)濾除菌后使用。

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產(chǎn)品名稱：
2',3'-Dideoxyadenosine
目錄號(hào)：
HY-W013441
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