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  1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Indole-3-carboxaldehyde

Indole-3-carboxaldehyde  (Synonyms: 3-Formylindole)

目錄號(hào): HY-W007376 純度: 99.96%
COA 產(chǎn)品使用指南 技術(shù)支持

Indole-3-carboxaldehyde (3-Formylindole) 是一種板藍(lán)根提取物,是由黃化豌豆幼苗的粗酶制劑氧化降解IAA 的產(chǎn)物。Indole-3-carboxaldehyde 可用于制備吲哚類植物抗毒素環(huán)蕓香素類似物。Indole-3-carboxaldehyde 還可以增強(qiáng)腸道上皮屏障和抗炎活性。

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Indole-3-carboxaldehyde Chemical Structure

Indole-3-carboxaldehyde Chemical Structure

CAS No. : 487-89-8

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10 mM * 1 mL in DMSO ¥550
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100 mg ¥500
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500 mg ¥1250
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Customer Review

Other Forms of Indole-3-carboxaldehyde:

MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻(xiàn)

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Indole-3-carboxaldehyde (3-Formylindole), a banlangen extract, is the product of the oxidative degradation of indole-3-acetic acid (IAA) by crude enzyme preparations from etiolated pea seedlings. Indole-3-carboxaldehyde is a biochemical used to prepare analogs of the indole phytoalexin cyclobrassinin. Indole-3-carboxaldehyde also enhances the epithelial barrier and anti-inflammatory activity in the intestinal tract[1][2].

IC50 & Target

Human Endogenous Metabolite

 

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
BV-2 IC50
0.76 μM
Compound: 11
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction based assay
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction based assay
[PMID: 27919656]
HeLa IC50
> 100 μM
Compound: 7
Antiproliferative activity against human Hela cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Antiproliferative activity against human Hela cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 32531682]
HeLa S3 IC50
> 10 μM
Compound: 8
Cytotoxicity against human HeLa S3 cells assessed as cell viability incubated for 48 hrs by microscopic analysis
Cytotoxicity against human HeLa S3 cells assessed as cell viability incubated for 48 hrs by microscopic analysis
[PMID: 35704432]
L5178Y IC50
0.069 μM
Compound: 18
Anticancer activity against mouse L5178Y assessed as cell growth inhibition by [3H]-thymidine assay
Anticancer activity against mouse L5178Y assessed as cell growth inhibition by [3H]-thymidine assay
[PMID: 33940466]
體外研究
(In Vitro)

Indole-3-carboxaldehyde (100 nM, 12 h) 增加內(nèi)皮型一氧化氮合酶 (eNOS) 轉(zhuǎn)錄水平,降低 VCAM、CCL2 和 IL6 基因表達(dá),降低 HUVECs 中 ROS 水平[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

145.16

Formula

C9H7NO

CAS 號(hào)
性狀

固體

顏色

Off-white to yellow

結(jié)構(gòu)分類
初始來(lái)源