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  2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism
  4. McN3716

McN3716  (Synonyms: Methyl palmoxirate; NSC359682)

目錄號(hào): HY-U00159
COA 產(chǎn)品使用指南

McN3716 是一種肉堿棕櫚酰轉(zhuǎn)移酶 I (CPT-1) 抑制劑。

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McN3716 Chemical Structure

McN3716 Chemical Structure

CAS No. : 69207-52-9

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規(guī)格 價(jià)格 是否有貨
1 mg ￥3950
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MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻(xiàn)

  • 生物活性

  • 實(shí)驗(yàn)參考方法

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

McN3716 is a carnitine palmitoyltransferase I (CPT-1) inhibitor.

IC50 & Target

Carnitine palmitoyltransferase I (CPT-1)[1]
體內(nèi)研究
(In Vivo)

Inhibition of brain mitochondrial β-oxidation by McN3716 (Methyl palmoxirate, MEP) significantly reduces the levels of all measured HETE and epoxytrienoic acids (EET), nonenzymatic auto-oxidative metabolites of ARA, by 23% to 44% and 32% to 50% compared with vehicle-injected rats, respectively, except for 15-HETE which was unaffected. There is a significant 34% reduction in the level of 6-keto-PGF1α, a byproduct of PGI2 (prostacyclin) in McN3716-treated rats. Similarly, the brain level of hydroxyeicosapentaenoic acids, nonenzymatic auto-oxidative metabolites of EPA, is reduced by 35% to 76% upon McN3716 treatment relative to vehicle[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

298.46

Formula

C18H34O3
CAS 號(hào)
性狀

固體

顏色

White to off-white

中文名稱

帕莫酸甲酯
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
純度 & 產(chǎn)品資料
參考文獻(xiàn)
Animal Administration
[1]

Rats[1]
Male Sprague Dawley rats are used. The rats receive ad libitum access to standard chow and water. At 15 weeks of age, six rats were subjected to either high-energy, head-focused microwave irradiation or CO2 asphyxiation. A separate group of 11 rats were implanted with a tail vein catheter (intravenous catheter 24 gauge/0.75 inch) and received either an intravenous injection of vehicle or 10?mg/kg of McN3716. Fifteen minutes after injection, rats were rapidly euthanized by high-energy, head-focused microwave irradiation (13.5?kW for 1.6?seconds) to avert ischemia for accurate quantification of in vivo basal levels of nonenzymatic auto-oxidative PUFA metabolites and enzymatically derived metabolites. Previously, we reported that this method reduced β-oxidation of fatty acid by 23% to 74%. McN3716 (Methyl palmoxirate, MEP) readily crosses the blood–brain barrier with a plasma half-life of 0.6?minute in the rat. The brain was excised and stored at -80°C for lipidomics profiling.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
參考文獻(xiàn)

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  • 稀釋計(jì)算器

The molarity calculator equation

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質(zhì)量   濃度   體積   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
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McN3716
目錄號(hào)：
HY-U00159
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