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  4. Dixyrazine

Dixyrazine  (Synonyms: 地西拉嗪)

目錄號: HY-U00153 純度: 99.87%
COA 產(chǎn)品使用指南

Dixyrazine 是 Phenothiazine 衍生物，可預防注射硫酸魚精蛋白引起的腦水腫。

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Dixyrazine Chemical Structure

Dixyrazine Chemical Structure

CAS No. : 2470-73-7

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥4704
In-stock
1 mg ￥2400
In-stock
5 mg ￥5000
In-stock
10 mg 現(xiàn)貨 詢價
50 mg   詢價  
100 mg   詢價  

* Please select Quantity before adding items.

Other Forms of Dixyrazine:

  • 生物活性

  • 實驗參考方法

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Dixyrazine, a phenothiazine derivative, can prevent brain oedema induced by intracarotid injection of protamine sulphate.

體內研究
(In Vivo)

Pretreatment with Dixyrazine 10 mg/kg completely prevents the brain oedema and significantly reduces the albumin increase in cerebrospinal fluid (CSF)[1]. The phenothiazine Dixyrazine (5 mg/kg i.v.) has minimal, transient hypotensive effects but significantly reduces the leakage of 126I labelled serum albumin in conscious rats subjected to acute hypertension provoked by i.v. Adrenaline or Bicuculline. The diameters of pial arteries and veins are continuously measured with a multichannel videoangiometer through a closed cranial window in anesthetized rats before and after i.v. injection of Dixyrazine (5 mg/kg). Dixyrazine, 5 mg /kg, induces a slight transitory decrease in blood pressure (10-20 mm Hg). Maximum MAP is slightly but not significantly lower in Dixyrazine-treated rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

427.60

Formula

C24H33N3O2S
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

地西拉嗪
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : 100 mg/mL (233.86 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質量 1 mg 5 mg 10 mg
1 mM 2.3386 mL 11.6932 mL 23.3863 mL
5 mM 0.4677 mL 2.3386 mL 4.6773 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內使用， -20°C儲存時，請在1年內使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.87%

參考文獻
Animal Administration
[2]

Rats[2]
Male Sprague-Dawley rats (200-225 g) are used. Evans blue and 125I-HSA are used as tracers, and controls are compared to rats pretreated with Dixyrazine 5 mL/kg or 15 mg/kg. The lower dose is given 15-20 min before the infusion of urea (that is the same interval as in the hypertension experiments). Because of larger effects on blood pressure with higher doses, the interval has to be extended to 40 min in this group. The radioactivity is determined in the right and left hemisphere and related to the activity in the blood.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
參考文獻

Dixyrazine 相關分類

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內使用， -20°C儲存時，請在1年內使用。

可選溶劑 濃度 溶劑體積 質量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3386 mL 11.6932 mL 23.3863 mL 58.4659 mL
5 mM 0.4677 mL 2.3386 mL 4.6773 mL 11.6932 mL
10 mM 0.2339 mL 1.1693 mL 2.3386 mL 5.8466 mL
15 mM 0.1559 mL 0.7795 mL 1.5591 mL 3.8977 mL
20 mM 0.1169 mL 0.5847 mL 1.1693 mL 2.9233 mL
25 mM 0.0935 mL 0.4677 mL 0.9355 mL 2.3386 mL
30 mM 0.0780 mL 0.3898 mL 0.7795 mL 1.9489 mL
40 mM 0.0585 mL 0.2923 mL 0.5847 mL 1.4616 mL
50 mM 0.0468 mL 0.2339 mL 0.4677 mL 1.1693 mL
60 mM 0.0390 mL 0.1949 mL 0.3898 mL 0.9744 mL
80 mM 0.0292 mL 0.1462 mL 0.2923 mL 0.7308 mL
100 mM 0.0234 mL 0.1169 mL 0.2339 mL 0.5847 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Dixyrazine
目錄號：
HY-U00153
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