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  2. Immunology/Inflammation
  3. Interleukin Related
  4. Simlukafusp alfa

Simlukafusp alfa  (Synonyms: FAP-IL2v)

目錄號(hào): HY-P99902 純度: 95.90%
COA

Simlukafusp alfa (FAP-IL2v) 是一種免疫細(xì)胞因子，包括一種抗成纖維細(xì)胞活化蛋白 α (FAPα) 的抗體和一種只結(jié)合 IL-2Rβγ 的 IL-2 變體。Simlukafusp alfa 是一種人 IgG1 抗體。

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CAS No. : 1776942-10-9

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規(guī)格 價(jià)格 是否有貨 數(shù)量
500 μg ￥6800
In-stock
1 mg ￥10800
In-stock
5 mg   詢價(jià)  
10 mg   詢價(jià)  

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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Simlukafusp alfa (FAP-IL2v) is an immunocytokine comprising an antibody against fibroblast activation protein α (FAPα) and an IL-2 variant that only binds IL-2Rβγ. Isotype: human IgG1[1].

同型

Human IgG1 kappa
推薦同型對(duì)照抗體
種屬

Fusion Protein
體外研究
(In Vitro)

Simlukafusp alfa (FAP-IL2v) 與 huIL-2Rβγ、cyIL-2Rβγ、muIL-2Rβγ、huFAP、cyFAP 和 muFAP的結(jié)合常數(shù)分別為 43±9 pM、80±20 pM、660±80 pM、0.3 nM、0.23 nM 和 0.5 nM[1]。
Simlukafusp alfa (0-100 nM; 5 days) 在體外激活 CD4+/CD8+ T 細(xì)胞和 NK 細(xì)胞，但不優(yōu)先激活 Tregs[1]。
Simlukafusp alfa (0-100 nM) 體外增強(qiáng) Cetuximab (HY-P9905) 介導(dǎo)的抗體依賴細(xì)胞毒性 (ADCC) 和 Cibisatamab (HY-P99011) 介導(dǎo)的 T 細(xì)胞依賴細(xì)胞毒性 (TDCC)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: NK cells, CD4+ and CD8+ T cells
Concentration: 0-100 nM
Incubation Time: 5 days
Result: Induced a dose-dependent proliferation of resting NK cells and resting and activated CD4+ and CD8+ T cells within peripheral blood mononuclear cells (PBMCs).
體內(nèi)研究
(In Vivo)

Simlukafusp alfa (FAP-IL2v) (1 mg/kg; i.v.; weekly for 4 weeks) 在人類癌癥小鼠模型中與處理性抗體聯(lián)合有效[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: huCD16-transgenic SCID mice, lung orthotopic xenograft A549 model[1]
Dosage: 1 mg/kg in combination with 25 mg/kg Cetuximab (HY-P9905) as single agents
Administration: IV, weekly starting at Day 14 for 4 weeks
Result: Achieved greater tumor control than either agent given as monotherapy. Reduced tumor volume and tumor growth.
Animal Model: CD-1 mice[1]
Dosage: 1, 2 or 4 mg/kg
Administration: IV (Pharmacokinetic Analysis)
Result: Pharmacokinetic parameters after first dose of human FAP-IL2v (huFAP-IL2v) in CD-1 mice
CD-1 mice (n=10 per group) were given 1, 2, and 4 mg/kg huFAP-IL2v by IV administration once weekly. Multiple IV doses at 1 and 2 mg/kg were administered QW for up to a maximum of three doses, at which point toxicity was observed. Only a single dose was administered to the 4-mg/kg IV treatment group because of toxicity in these treatment groups. Blood was sampled at 0.5, 6, 24, 48, 72, and 168 h.
huFAP-IL2v dose (mg/kg) Cmax (μg/mL) AUC0-168h (μg?h/mL per mg/kg) CL (mL/d/kg)
1 19.0 557 40.0
2 36.3 479 46.8
4 78.7 541 38.7

AUC0-168h, area under the concentration-time curve from 0 to 168 hours; Cmax, maximum serum concentration observed; CL, total clearance; FAP-IL2v, fibroblast activation protein-α -targeted interleukin 2 variant (IL2v) immunocytokine; hu, humanized; IV, intravenous.
Clinical Trial
CAS 號(hào)
性狀

液體

顏色

Colorless to light yellow

運(yùn)輸條件

Shipping with dry ice.
儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
純度 & 產(chǎn)品資料
參考文獻(xiàn)

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  • 稀釋計(jì)算器

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The dilution calculator equation

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Simlukafusp alfa
目錄號(hào)：
HY-P99902
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