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  2. Immunology/Inflammation
  3. Interleukin Related
  4. Siltuximab

Siltuximab  (Synonyms: 司妥昔單抗; CNTO-328)

目錄號: HY-P9956 純度: ≥99.0%
COA 技術(shù)支持

Siltuximab 是一種 anti-IL-6 (interleukin-6) 單克隆抗體，具有抗腫瘤活性。Siltuximab 可用于多中心性巨大淋巴結(jié)增生癥 (MCD) 和 COVID-19 的研究。

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CAS No. : 541502-14-1

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥1900
In-stock
5 mg ￥5700
In-stock
10 mg ￥9120
In-stock
50 mg   詢價  
100 mg   詢價  

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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Siltuximab is an anti-IL-6 (interleukin-6) monoclonal antibody, and shows antitumor activity. Siltuximab can be used in Multicentric Castleman's Disease (MCD) and COVID-19 research[1][2][3].

同型

Human IgG1(E356D/M358L) kappa
推薦同型對照抗體
種屬

Chimeric
體內(nèi)研究
(In Vivo)

Siltuximab (intraperitoneal injection; 10 mg/kg; 3 times per week) inhibits the growth of lung cancer cells in xenograft mouse model[1].
Siltuximab (intraperitoneal injection; 20 mg/kg; twice per week; 6 w) inhibits the growth of MCF-7 tumor in xenograft model[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CD-1 nu/nu mice injected with H1650 (adenocarcinoma), H322 (adenocarcinoma), or H157 (squamous) cells[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; 10 mg/kg; 3 times per week
Result: Repressed PY-STAT3 levels stimulated by IL-6 in H322 cells.
Repressed PY-STAT3 levels in H1650 cells.
Inhibited the growth of tumors with H322 and CAF cells.
Inhibited the growth of tumors with H1650 and CAF cells.
Animal Model: Female NOD-SCID mice with MCF-7 tumor[4]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection; 20 mg/kg; twice per week; 6 weeks
Result: Blocked MCF-7 engraftment, induced regressions in 90% of tumors.
Clinical Trial
CAS 號
性狀

液體

顏色

Colorless to light yellow

中文名稱

司妥昔單抗；塞妥昔單抗
運輸條件

Shipping with dry ice.
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
純度 & 產(chǎn)品資料

純度: ≥99.0%

參考文獻

  • 摩爾計算器

  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Siltuximab
目錄號：
HY-P9956
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