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  2. Immunology/Inflammation
  3. Interleukin Related
  4. Mepolizumab

Mepolizumab  (Synonyms: 美泊利單抗; SB 240563)

目錄號: HY-P9945 純度: 98.00%
COA 技術(shù)支持

Mepolizumab (SB 240563) 是一種人源化的單克隆抗體，可結(jié)合并中和白細胞介素 5 (IL-5)，白細胞介素 5 (IL-5) 是參與嗜酸性粒細胞增殖、活化和存活的主要細胞因子。Mepolizumab 可用于嗜酸性肉芽腫伴多血管炎 (EGPA) 和重度嗜酸性哮喘的研究。

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CAS No. : 196078-29-2

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥1800
In-stock
5 mg ￥4500
In-stock
10 mg   詢價  
50 mg   詢價  

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Customer Review

Other Forms of Mepolizumab:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Mepolizumab (SB 240563) is a humanized monoclonal antibody that binds to and neutralizes interleukin-5 (IL-5), the major cytokine involved in eosinophil proliferation, activation, and survival. Mepolizumab can be used for the research of eosinophilic granulomatosis with polyangiitis (EGPA) and severe eosinophilic asthma[1][2].

同型

Human IgG1 kappa
推薦同型對照抗體
種屬

Humanized
體外研究
(In Vitro)

Mepolizumab shows nearly linear PK after intravenous administration over a 6000-fold dose range (0.05-300 mg/kg), inhibiting eosinophil proliferation with an IC50 of 1.43 mg/mL[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Mepolizumab 靜脈給藥超過 6000 倍劑量范圍 (0.05-300 mg/kg) 后，觀察到近似線性的 PK，抑制嗜酸性粒細胞增殖，IC50 為 1.43 mg/mL[1]。
Mepolizumab 在食蟹猴體內(nèi)的藥代動力學(xué)分析[1]

Route Dose (mg/kg) Cmax (μg/mL) AUC0-INF_obs (μg·h/mL) T1/2 (days) Clobs (mL·h/kg) Vss_obs (mL/kg)
i.v. 300 6700 1405000 11.7 0.217 74.6
i.v. 3 89.1 14600 11.2 0.208 82.1

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS 號
性狀

液體

顏色

Colorless to light yellow

中文名稱

美泊利單抗； 美泊麗珠單抗
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
純度 & 產(chǎn)品資料
參考文獻

  • 摩爾計算器

  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Mepolizumab
目錄號：
HY-P9945
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