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  2. GPCR/G Protein Immunology/Inflammation
  3. CXCR
  4. Ulocuplumab

Ulocuplumab  (Synonyms: 烏洛魯單抗; BMS 936564; MDX 1338; Anti-Human CXCR4 Recombinant Antibody)

目錄號(hào): HY-P99272 純度: 99.90%
COA 技術(shù)支持

Ulocuplumab (Anti-Human CXCR4 Recombinant Antibody/BMS-936564/MDX1338) 是一種完全人 IgG4 抗 CXCR4 抗體。Ulocplumab 誘導(dǎo)癌細(xì)胞凋亡 (apoptosis)，能夠抑制 CXCL12 介導(dǎo)的慢性淋巴細(xì)胞白血病 (CLL) 細(xì)胞在 CXCR4 激活下的遷移。Ulocplumab 在急性髓系白血病 (AML)，非霍奇金淋巴瘤 (NHL) 和多發(fā)性骨髓瘤移植模型中顯示抗腫瘤活性。

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CAS No. : 1375830-34-4

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查看 CXCR 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Ulocuplumab (Anti-Human CXCR4 Recombinant Antibody/BMS-936564/MDX1338) is a fully human IgG4 anti-CXCR4 antibody. Ulocuplumab induces apoptosis and inhibits CXCL12 mediated CXCR4 activation-migration of chronic lymphocytic leukemia (CLL). Ulocuplumab exhibits antitumor activity in established tumors including acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL), and multiple myeloma xenograft models[1][2].

同型

Human IgG4 kappa
推薦同型對(duì)照抗體
種屬

Human
IC50 & Target[1][2]

CXCR4

 

體外研究
(In Vitro)

Ulocplumab (0-100 μM; 48 h) 缺乏抗體依賴的細(xì)胞細(xì)胞毒性 (ADCC) 或補(bǔ)體 (CDC) 活性，但也在 Ramos 細(xì)胞和 CLL 或癌細(xì)胞系中誘導(dǎo) CXCR4 結(jié)合介導(dǎo)的凋亡，也在 CLL 患者的原發(fā)性白血病細(xì)胞中顯示促凋亡[1]。
Ulocplumab (0.2 μM, 2 μM; 15 s) 抑制 F-actin 聚合，降低對(duì) CXCL12 的峰響應(yīng)，(20 nM-2 μM; 1 h) 還抑制細(xì)胞遷移[1]。
Ulocplumab (200 nM; 6 h) 具有獨(dú)立于 caspase 的程序性細(xì)胞死亡 (PCD) 誘導(dǎo)作用[1]。
Ulocplumab (10 μg/mL; 4 h) 在CLL細(xì)胞中通過產(chǎn)生活性氧 (ROS) 誘導(dǎo)細(xì)胞死亡[1]。
Ulocplumab 抑制 CXCL12 誘導(dǎo)的鈣通量，在 Ramos 中 EC50 為 10 nM [2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: Ramos cells and primary leukemia cells (from CLL patients)
Concentration: 0-100 μM
Incubation Time: 48 hours
Result: Induced apoptosis in Ramos cells with an IC50 value of 1.9 nM and showed pro-apoptotic with an IC50 value of 12.43 nM in primary leukemia cells from CLL patients.
體內(nèi)研究
(In Vivo)

Ulocplumab (3-30 mg/kg; 腹腔注射; 3-4 天 5 次劑量; 共 65 天) 抑制小鼠多發(fā)性骨髓瘤異種移植瘤模型的腫瘤生長(zhǎng)，包括帶有 Ramos B 細(xì)胞、HL-60 細(xì)胞、MOLP-8 細(xì)胞、Nomo-1 細(xì)胞和 JJN-3R 細(xì)胞的腫瘤模型[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Severe combined immunodeficient (SCID) mice of AML model (MOLP-8 cells)[1]
Dosage: 3-30 mg/kg
Administration: Intraperitoneal injection; every 3-4 days for 5 doses; last for 65 days
Result: Significantly delayed mean tumor growth by 66% and 56% when compared with isotype control on day 25.
Clinical Trial
CAS 號(hào)
性狀

液體

顏色

Colorless to light yellow

中文名稱

烏洛魯單抗
運(yùn)輸條件

Shipping with dry ice.
儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
Biological Activity
  • Immobilized Human CXCR4/CD184 Protein can bind Ulocuplumab. The EC50 for this effect is 47.58 ng/mL.
純度 & 產(chǎn)品資料
參考文獻(xiàn)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Ulocuplumab
目錄號(hào)：
HY-P99272
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