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  2. Inhibitory Antibodies
  3. Zolbetuximab

Zolbetuximab  (Synonyms: 佐妥昔單抗; IMAB362)

目錄號: HY-P99058 純度: 96.98%
COA 技術(shù)支持

Zolbetuximab (IMAB362) 是一種靶向 Claudin-18.2 的單克隆抗體。Zolbetuximab 通過免疫效應(yīng)機(jī)制介導(dǎo)對 Claudin-18.2 陽性細(xì)胞的特異性殺傷。Zolbetuximab 可用于胃腸道腺癌和胰腺腫瘤的研究。

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CAS No. : 1496553-00-4

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥2800
In-stock
5 mg ￥7900
In-stock
10 mg   詢價  
50 mg   詢價  

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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Zolbetuximab (IMAB362) is a monoclonal antibody targeting Claudin-18.2. Zolbetuximab mediates specific killing of Claudin-18.2-positive cells through immune effector mechanisms. Zolbetuximab can be used for the research of gastrointestinal adenocarcinomas and pancreatic tumors[1].

同型

Human IgG1 kappa
推薦同型對照抗體
種屬

Chimeric
體外研究
(In Vitro)

Zolbetuximab (0-100 μg/mL) 與 CLDN18.2+ PC 細(xì)胞結(jié)合，誘導(dǎo)抗體依賴性細(xì)胞毒性 (ADCC) 和補(bǔ)體依賴性細(xì)胞毒性 (CDC)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

單獨使用 Zolbetuximab (200 μg，靜脈注射) 以及與 Gemcitabine (HY-17026) (50 mg/kg，腹腔注射) 聯(lián)合使用，在小鼠 BxPC-3-CLDN18.2 異種移植模型中表現(xiàn)出抗腫瘤活性[2]。
Zolbetuximab (5.7 mg/kg，腹腔注射，每周 3 次，持續(xù)五周) 抑制 SNU-620 細(xì)胞異種移植模型中的腫瘤生長[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: mouse BxPC-3-CLDN18.2, MIA PaCa-2-CLDN18.2 xenograft model[2]
Dosage: 200 μg alone or with 50 mg/kg Gemcitabine
Administration: i.v.; i.p. (Gemcitabine)
Result: Inhibited tumor growth in two models, and prevented lung metastasis formation.
Prolonged survival time, and lowered fractions of CLDN18.2+ cells in MIA PaCa-2-CLDN18.2 xenograft.
Clinical Trial
CAS 號
性狀

液體

顏色

Colorless to light yellow

中文名稱

佐妥昔單抗
運輸條件

Shipping with dry ice.
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
純度 & 產(chǎn)品資料

純度: 96.98%

參考文獻(xiàn)

  • 摩爾計算器

  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Zolbetuximab
目錄號：
HY-P99058
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