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  2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. Tislelizumab

Tislelizumab  (Synonyms: 替雷利珠單抗)

目錄號: HY-P99052 純度: 98.10%
COA 技術(shù)支持

Tislelizumab 是一種能特異性結(jié)合細(xì)胞程序性死亡受體 1 (PD-1) 的單克隆抗體，阻斷其與程序性死亡配體 1 (PD-L1) 和程序性死亡配體 2 (PD-L2) 的相互作用。Tislelizumab 可使 T 淋巴細(xì)胞等免疫細(xì)胞重新激活，增強抗腫瘤的活性。Tislelizumab 被用于經(jīng)典型霍奇金淋巴瘤、尿路上皮癌、非小細(xì)胞肺癌和肝細(xì)胞癌等多種腫瘤的研究。

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CAS No. : 1858168-59-8

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥1200
In-stock
5 mg ￥3500
In-stock
10 mg ￥5500
In-stock
25 mg ￥8625
In-stock
50 mg ￥11388
In-stock
100 mg ￥15360
In-stock
200 mg   詢價  
500 mg   詢價  

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Customer Review

MCE 顧客使用本產(chǎn)品發(fā)表的 2 篇科研文獻

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Tislelizumab is a monoclonal antibody that specifically binds to programmed cell death receptor 1 (PD-1), blocking its interaction with programmed death ligand 1 (PD-L1) and programmed death ligand 2 (PD-L2). Tislelizumab can reactivate immune cells such as T lymphocytes and enhance anti-tumor activity. Tislelizumab can be used for the research of a variety of tumors including typical Hodgkin's lymphoma, urothelial carcinoma, non-small cell lung cancer and hepatocellular carcinoma[1][2][3].

同型

Human IgG4 kappa
推薦同型對照抗體
種屬

Humanized
體內(nèi)研究
(In Vivo)

Tislelizumab (10 mg/kg; 腹腔注射; 每周一次; 4 周) 在 B16F10 黑色素瘤小鼠模型中具有顯著的抗腫瘤作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: B16F10/GM-CSF tumor cells treated hPD-1 C57BL/6 transgenic mice[2]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection (i.p.); once a week for 4 weeks.
Result: Exerted remarkable antitumor efficacy, resulting in approximate 86.7% tumor growth inhibition.
Clinical Trial
CAS 號
性狀

液體

顏色

Colorless to light yellow

儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
Biological Activity
  • Flow cytometry analysis of PD-1 overexpression Jurkat cells labelling PD-1 with Tislelizumab at 20 nM (Red). Goat anti human IgG Fc (Alexa Fluor488) was used as the secondary antibody at 1/1000 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).
純度 & 產(chǎn)品資料

純度: 98.10%

參考文獻

  • 摩爾計算器

  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Tislelizumab
目錄號：
HY-P99052
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