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  2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Panitumumab

Panitumumab  (Synonyms: 帕尼單抗; ABX-EGF)

目錄號: HY-P99041 純度: 98.80%
COA 技術支持

Panitumumab (ABX-EGF) 是一種全人源 IgG2 抗 EGFR 單克隆抗體，具有抗腫瘤活性。Panitumumab 抑制腫瘤細胞增殖、存活和血管生成。Panitumumab 可用于癌癥研究，例如結(jié)腸癌。

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CAS No. : 339177-26-3

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1 mg ￥1850
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10 mg ￥8960
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MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Panitumumab (ABX-EGF) is a fully human IgG2 anti-EGFR monoclonal antibody with anti-tumor activity. Panitumumab inhibits tumor cell proliferation, survival and angiogenesis. Panitumumab can be used in the research of cancers, such as colon cancer[1][2][4].

同型

Human IgG2 kappa
推薦同型對照抗體
種屬

Human
體外研究
(In Vitro)

Panitumumab (2 nM-2 μM，3 小時) 抑制表達 EGFR 的 NCI-H1975 細胞、NCI-H1650 細胞和 CHO 細胞中的配體依賴性自磷酸化[3]。
Panitumumab (0 -200 μg/mL，48 h) 抑制DLD-1細胞增殖[4]。
Panitumumab (80 μg/mL，24 h) 增加beclin-1 (一種標志物自噬) 在 Caco-2 細胞和 DLD-1 細胞中的水平[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[3]

Cell Line: EGFR-expressing NCI-H1975 cells, NCI-H1650 cells and CHO cells
Concentration: 2, 20, 200, 2000 nM
Incubation Time: 3 h
Result: Inhibited ligand-induced autophosphorylation of EGFR.
體內(nèi)研究
(In Vivo)

Panitumumab (2 nM-2 μM，3 小時) 抑制表達 EGFR 的 NCI-H1975 細胞、NCI-H1650 細胞和 CHO 細胞中的配體依賴性自磷酸化[3]。
Panitumumab (0 -200 μg/mL，48 h) 抑制DLD-1細胞增殖[4]。
Panitumumab (80 μg/mL，24 h) 增加beclin-1 (一種標志物自噬) 在 Caco-2 細胞和 DLD-1 細胞中的水平[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NCI-H1975 and NCI-H1650 xenografts[3]
Dosage: 25, 100, or 500 μg/mouse
Administration: Intraperitoneal injection (i.p.), twice a week
Result: Inhibited ligand-induced EGFR phosphorylation, tumor growth, and markers of proliferation.
Decreased Ki-67 and phospho- mitogen-activated protein kinase (pMAPK) staining in both xenografts.
Clinical Trial
CAS 號
性狀

液體

顏色

Colorless to light yellow

中文名稱

帕尼單抗； 帕尼單抗
運輸條件

Shipping with dry ice.
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG2 kappa
Biological Activity
  • Immobilized EGFR Protein, Human can bind Panitumumab. The EC50 for this effect is 47.19 ng/mL.
  • Panitumumab has a significant ADCP effect on CHOK1-human EGFR cells in a dose-dependent manner.The EC50 for this effect is 130.4 ng/mL.
純度 & 產(chǎn)品資料

純度: 98.80%

參考文獻

  • 摩爾計算器

  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Panitumumab
目錄號：
HY-P99041
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