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  2. Cell Cycle/DNA Damage Immunology/Inflammation
  3. Checkpoint Kinase (Chk) IFNAR
  4. Monalizumab

Monalizumab  (Synonyms: 莫那利珠單抗; IPH2201)

目錄號(hào): HY-P99032 純度: 99.69%
COA

Monalizumab (IPH2201) 是一種靶向自然殺傷細(xì)胞群 2A (NKG2A) 的免疫檢查點(diǎn)抑制劑。Monalizumab 是一種人源化抗 NKG2A 的單克隆抗體，可增加 IFN-γ 產(chǎn)生，從而促進(jìn)自然殺傷細(xì)胞功能。Monalizumab 可用于頭頸部鱗狀細(xì)胞癌 (HNSCC) 的研究。

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CAS No. : 1228763-95-8

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥5300
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5 mg ￥11340
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10 mg ￥15240
In-stock
25 mg ￥22680
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50 mg ￥30600
In-stock
100 mg ￥41160
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200 mg   詢價(jià)  
500 mg   詢價(jià)  

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Customer Review

查看 Checkpoint Kinase (Chk) 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Monalizumab (IPH2201) is an immune checkpoint inhibitor targeting Natural Killer Group 2A (NKG2A). Monalizumab, a humanized anti-NKG2A blocking mAb, increases IFN-γ production, thereby promoting NK cell effector functions. Monalizumab can be used for the research of head and neck squamous cell carcinoma (HNSCC)[1][2].

同型

Human IgG4 kappa
推薦同型對(duì)照抗體
種屬

Humanized
體外研究
(In Vitro)

Monalizumab 阻斷 NKG2A 并增強(qiáng) CLL NK 細(xì)胞介導(dǎo)的針對(duì)表達(dá) HLA-E 的 K562 細(xì)胞的細(xì)胞毒性[3]。
Monalizumab 增強(qiáng) Enzalutamide (HY-70002) (10 μM) 誘導(dǎo)的 NK 細(xì)胞活化和殺傷前列腺癌細(xì)胞 (LNCaP 和 22Rv1)[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Monalizumab (50 μg，瘤內(nèi)注射，與 800 萬個(gè)活化的 NK 細(xì)胞一起) 可有效抑制免疫缺陷小鼠異種移植 HLA-E+ 腫瘤的腫瘤生長(zhǎng)[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: immunodeficient mice xenografted with Cal-27 HLA-E high tumor cell[4]
Dosage: 50?μg, together with 8?millions of activated NK cells
Administration: intratumoral injections
Result: Shows a synergestic antitumor effect.
Enhanced NK-cell killing, and induces lysis of tumor cells.
Clinical Trial
CAS 號(hào)
性狀

液體

顏色

Colorless to light yellow

中文名稱

莫那利珠單抗
運(yùn)輸條件

Shipping with dry ice.
儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
純度 & 產(chǎn)品資料

純度: 99.69%

參考文獻(xiàn)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Monalizumab
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