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  2. Immunology/Inflammation
  3. Interleukin Related
  4. Lebrikizumab

Lebrikizumab  (Synonyms: 來(lái)瑞組單抗; TNX-650)

目錄號(hào): HY-P99025 純度: 99.90%
COA 技術(shù)支持

Lebrikizumab (TNX-650) 是一種 IgG4 人源化的抗白細(xì)胞介素-13 (IL-13) 單克隆抗體，具有抗瘙癢的效果，能夠特異性結(jié)合到 IL-13 的非受體結(jié)合域，并抑制其功能。Lebrikizumab 抑制 IL-13 驅(qū)動(dòng)的 Th2 炎癥反應(yīng)，并阻斷 IL-4Rα/IL-13Rα1 的信號(hào)傳導(dǎo)。Lebrikizumab 可用于哮喘、特應(yīng)性皮炎和神經(jīng)炎癥性疾病的研究。

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CAS No. : 953400-68-5

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥3000
In-stock
5 mg ￥7800
In-stock
10 mg   詢價(jià)  
50 mg   詢價(jià)  

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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Lebrikizumab (TNX-650) is an IgG4 humanized anti-interleukin-13 (IL-13) mAb with anti-itch effects that specifically binds to IL-13 in a non-receptor binding domain and inhibits its function. Lebrikizumab inhibits the IL-13 driven Th2 inflammatory response and blocks the signaling of IL-4Rα/IL-13Rα1. Lebrikizumab can be used for the research of asthma, atopic dermatitis and neuroinflammatory diseases[1][2][3].

IC50 & Target

IL-13

 

體外研究
(In Vitro)

Lebrikizumab (500 μg/mL 或 1 mg/mL，24 小時(shí)) 在體外有效抑制了 IL-13 引發(fā)的神經(jīng)敏感反應(yīng)對(duì)每種三種瘙癢物質(zhì)的反應(yīng)[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS 號(hào)
性狀

液體

顏色

Colorless to light yellow

中文名稱

來(lái)瑞組單抗
運(yùn)輸條件

Shipping with dry ice.
儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
Biological Activity
  • Loaded Lebrikizumab on AHC2 biosensor, can bind IL-13 Protein, Human (HEK293, His, HY-P70568) with an affinity constant of 7.283E-10 M as determined in BLI assay.
純度 & 產(chǎn)品資料

純度: 99.90%

參考文獻(xiàn)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Lebrikizumab
目錄號(hào)：
HY-P99025
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