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  1. Stem Cell/Wnt TGF-beta/Smad
  2. TGF-beta/Smad
  3. Fresolimumab

Fresolimumab  (Synonyms: 非蘇木單抗; GC1008)

目錄號(hào): HY-P99020 純度: 99.51%
COA

Fresolimumab (GC1008) 是一種人源化抗 TGF-β 的單克隆抗體,可以中和所有哺乳動(dòng)物 TGF-β 的活性亞型。Fresolimumab 對(duì) TGF-β2 的結(jié)合親和力為 1.8 nM。用 89Zr 放射標(biāo)記的 Fresolimumab 可用于 PET 分析 TGF-β 的表達(dá)、抗體腫瘤攝取和器官分布。Fresolimumab 可用于癌癥、脆骨病、纖維化和腎臟疾病等的研究。

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CAS No. : 948564-73-6

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ¥5000
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5 mg ¥10500
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10 mg ¥14160
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25 mg ¥21000
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50 mg ¥28320
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100 mg ¥38280
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MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻(xiàn)

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Fresolimumab (GC1008) is a human monoclonal antibody against TGF-β that neutralizes all mammalian active subtypes of TGF-β. The binding affinity of Fresolimumab to TGF-β2 is 1.8 nM. Fresolimumab radiolabeled with 89Zr can be used for PET analysis of TGF-β expression, antibody uptake and organ distribution. Fresolimumab can be used in the study of cancer, osteogenesis imperfecta, fibrosis and kidney disease[1][2][3].

同型

Human IgG4 kappa

推薦同型對(duì)照抗體
種屬

Human

Clinical Trial
CAS 號(hào)
性狀

液體

顏色

Colorless to light yellow

中文名稱

非蘇木單抗

運(yùn)輸條件

Shipping with dry ice.

儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG4 kappa
Biological Activity
  • Immobilized TGF beta 1/TGFB1 Protein, Human can bind Fresolimumab. The EC50 for this effect is 67.28 ng/mL.
純度 & 產(chǎn)品資料

純度: 99.51%

參考文獻(xiàn)
  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱:
Fresolimumab
目錄號(hào):
HY-P99020
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