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  2. GPCR/G Protein Cell Cycle/DNA Damage Apoptosis
  3. Formyl Peptide Receptor (FPR) PERK Apoptosis
  4. WKYMVm

WKYMVm 是一種選擇性地甲酰肽受體 2 (FPR2) 激動劑。WKYMVm 具有強(qiáng)大的抗炎作用，可減輕肺損傷和脊髓損傷。WKYMVm 能夠通過調(diào)控脂質(zhì)代謝和瘦素信號傳導(dǎo)改善肥胖。WKYMVm 通過激活 FPRs 參與免疫細(xì)胞的調(diào)控，WKYMVm 能促進(jìn)免疫細(xì)胞的趨化遷移，抑制吞噬細(xì)胞的凋亡 (apoptosis)。此外，WKYMVm 在腫瘤中可能發(fā)揮有利或不利的作用，這取決于腫瘤的類型。

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Custom Peptide Synthesis

WKYMVm Chemical Structure

WKYMVm Chemical Structure

CAS No. : 187986-17-0

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥1636
In-stock
5 mg ￥3600
In-stock
10 mg ￥5580
In-stock
50 mg   詢價  
100 mg   詢價  

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Customer Review

Other Forms of WKYMVm:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

WKYMVm is a selective formylpeptide receptor 2 (FPR2) agonist. WKYMVm has a powerful anti-inflammatory effect that can reduce lung injury and spinal cord injury. WKYMVm ameliorates obesity by regulating lipid metabolism and leptin signaling. WKYMVm is involved in the regulation of immune cells by activating FPRs. WKYMVm can promote the chemotactic migration of immune cells and inhibit the apoptosis of phagocytes. In addition, WKYMVm may play a favorable or unfavorable role in tumors, depending on the type of tumor[1][2][3][4][5][6][7].

IC50 & Target

FPR1, FPRL1[1], FPRL2[2]
細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
HL-60 EC50
0.001 μM
Compound: WKYMVm
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
[PMID: 19639995]
HL-60 EC50
0.01 μM
Compound: WKYMVm
Agonist activity at FPRL2 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
Agonist activity at FPRL2 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
[PMID: 19639995]
HL-60 EC50
0.5 μM
Compound: WKYMVm
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
[PMID: 19639995]
體外研究
(In Vitro)

WKYMVm (0-5 μmol/L；2 小時 ) 在 LPS (HY-D1056) 處理的小膠質(zhì)細(xì)胞中抑制炎性細(xì)胞因子 (TNF-α, IL-6和 IL-1β) 的產(chǎn)生[3]。
WKYMVm (1-100 μM；0-24 小時) 在 HUVECs 細(xì)胞中可以增加 FPR2 mRNA 水平和 ERK 磷酸化水平，促進(jìn) HUVECs 管形成和細(xì)胞增殖[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

WKYMVm (4 mg/kg；腹腔注射；3 次；間隔 24 h) 在大鼠脊髓損傷模型中具有保護(hù)作用[3]。
WKYMVm (2.5 mg/kg；腹腔注射；4 天) 可減輕新生小鼠高氧誘導(dǎo)的肺損傷[4]。
WKYMVm (8?mg/kg；皮下注射；兩天一次；2-5 周) 可在高脂飼養(yǎng)的小鼠模型中改善肥胖[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult female Sprague-Dawley rats (200-220 g) with spinal cord injury[3]
Dosage: 4 mg/kg
Administration: Intraperitoneal injection (i.p.); 3 times with 24 hours intervals
Result: Reduce structural disorders and neuronal loss.
Reduced the phosphorylation of ERK1/2 and NF-κB p65 but not p38.
Animal Model: Normoxia or hyperoxic treated newborn mouse pups of C57/BL6[4]
Dosage: 2.5 mg/kg
Administration: Intraperitoneal injection (i.p.); daily from postnatal day (P) 5 to P8.
Result: Significantly attenuated hyperoxia-induced lung inflammation, as evidenced by increased inflammatory cytokines, neutrophils, and alveolar macrophages, and resultant lung injuries, which included impaired alveolarization and angiogenesis, an increased number of apoptotic cells, and reduced levels of growth factors in vivo, such as vascular endothelial growth factor and hepatocyte growth factor.
Animal Model: High fat diet treated male wild-type C57BL/6N mice aged 8 weeks old (21?±?2?g)[5]
Dosage: 8?mg/kg
Administration: Subcutaneous injection (i.h.); once every 2?days; 2 or 5 weeks
Result: Significantly attenuated body weight gain, food intake and increased insulin sensitivity.
Markedly ameliorated HFD-induced hepatic steatosis and adipose tissue hypertrophy.
Improved lipid metabolism in adipose tissue.
Improved leptin signalling in the hypothalamus.
分子量

856.11

Formula

C41H61N9O7S2
CAS 號
性狀

固體

顏色

White to off-white

Sequence

Trp-Lys-Tyr-Met-Val-{d-Met}-NH2
Sequence Shortening

WKYMV-{d-Met}-NH2
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性數(shù)據(jù)
細(xì)胞實驗： 

H2O 中的溶解度 : 12.5 mg/mL (14.60 mM; 超聲助溶)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 1.1681 mL 5.8404 mL 11.6807 mL
5 mM 0.2336 mL 1.1681 mL 2.3361 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
您所需的儲備液濃度超過該產(chǎn)品的實測溶解度，如有需要，請與 MCE 中國技術(shù)支持聯(lián)系。
純度 & 產(chǎn)品資料
參考文獻(xiàn)

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.1681 mL 5.8404 mL 11.6807 mL 29.2019 mL
5 mM 0.2336 mL 1.1681 mL 2.3361 mL 5.8404 mL
10 mM 0.1168 mL 0.5840 mL 1.1681 mL 2.9202 mL

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
WKYMVm
目錄號：
HY-P1120
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