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  2. Cytoskeleton Anti-infection
  3. Arp2/3 Complex Fungal
  4. Jasplakinolide

Jasplakinolide 是一種有效的肌動(dòng)蛋白聚合反應(yīng) (actin polymerization) 誘導(dǎo)劑，可以穩(wěn)定先前存在的肌動(dòng)蛋白絲。Jasplakinolide 與鬼筆環(huán)肽競(jìng)爭(zhēng)性結(jié)合 F-肌動(dòng)蛋白，Kd 值為 15 nM。Jasplakinolide 是一種來(lái)自海洋海綿 (marine sponge) 的天然環(huán)狀肽，具有抗真菌和抗腫瘤活性。

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Jasplakinolide Chemical Structure

Jasplakinolide Chemical Structure

CAS No. : 102396-24-7

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規(guī)格 價(jià)格 是否有貨 數(shù)量
50 μg ￥4500
In-stock
100 μg 現(xiàn)貨 詢(xún)價(jià)

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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a Kd of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity[1][2].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
786-0 GI50
0.02 μM
Compound: 1
Growth inhibition of human 786-0 cells by sulforhodamine B assay
Growth inhibition of human 786-0 cells by sulforhodamine B assay
[PMID: 20121114]
CA46 IC50
0.03 μM
Compound: 5
Antiproliferative activity against human CA46 cells after 24 hrs
Antiproliferative activity against human CA46 cells after 24 hrs
[PMID: 12088429]
CA46 IC50
10 nM
Compound: 1
Growth inhibition of human CA46 cells assessed as induction of actin assembly after 24 hrs
Growth inhibition of human CA46 cells assessed as induction of actin assembly after 24 hrs
[PMID: 20678932]
HCT-116 GI50
0.1 μM
Compound: 1
Growth inhibition of human HCT116 cells by sulforhodamine B assay
Growth inhibition of human HCT116 cells by sulforhodamine B assay
[PMID: 20121114]
HCT-15 GI50
0.69 μM
Compound: 1
Growth inhibition of human HCT15 cells by sulforhodamine B assay
Growth inhibition of human HCT15 cells by sulforhodamine B assay
[PMID: 20121114]
HOP-62 GI50
0.15 μM
Compound: 1
Growth inhibition of human HOP62 cells by sulforhodamine B assay
Growth inhibition of human HOP62 cells by sulforhodamine B assay
[PMID: 20121114]
KB IC50
0.013 μM
Compound: 1, jasplakinolide
Growth inhibition of human KB cells after 72 hrs by CellTiter 96 assay
Growth inhibition of human KB cells after 72 hrs by CellTiter 96 assay
[PMID: 22364566]
M14 GI50
0.056 μM
Compound: 1
Growth inhibition of human M14 cells by sulforhodamine B assay
Growth inhibition of human M14 cells by sulforhodamine B assay
[PMID: 20121114]
OVCAR-3 GI50
0.04 μM
Compound: 1
Growth inhibition of human OVCAR-3 cells by sulforhodamine B assay
Growth inhibition of human OVCAR-3 cells by sulforhodamine B assay
[PMID: 20121114]
SF-539 GI50
0.3 μM
Compound: 1
Growth inhibition of human SF539 cells by sulforhodamine B assay
Growth inhibition of human SF539 cells by sulforhodamine B assay
[PMID: 20121114]
體外研究
(In Vitro)

Jasplakinolide has an IC50 of 35 nM for the antiproliferative effect of jasplakinolide on PC3 prostate carcinoma cells[2].
Jasplakinolide (10 μM; for 2 hours) generates binucleated cells when applied during mitosis. Jasplakinolide induces the formation of F-actin-containing apical extensions in Toxoplasma gondii tachyzoites[2].
Jasplakinolide (1 mM; for 60 min) induces the formation of actin-containing apical extensions in isolated Toxoplasma gondii tachyzoites fixed[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

709.67

Formula

C36H45BrN4O6
CAS 號(hào)
性狀

固體

顏色

White to off-white

結(jié)構(gòu)分類(lèi)
初始來(lái)源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : ≥ 2 mg/mL (2.82 mM; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開(kāi)封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 1.4091 mL 7.0455 mL 14.0911 mL
5 mM --- --- ---
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.5%

參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4091 mL 7.0455 mL 14.0911 mL 35.2276 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱(chēng)：
Jasplakinolide
目錄號(hào)：
HY-P0027
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