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  2. Apoptosis GPCR/G Protein
  3. Apoptosis Adenosine Receptor
  4. N6-Benzyladenosine

N6-Benzyladenosine  (Synonyms: Benzyladenosine)

目錄號(hào): HY-N7844 純度: 99.43%
COA 產(chǎn)品使用指南 技術(shù)支持

N6-Benzyladenosine 是一種腺苷受體激動(dòng)劑，具有細(xì)胞分裂素 (cytokinin) 活性。N6-Benzyladenosine 能將細(xì)胞周期阻滯在 G0/G1，并誘導(dǎo)凋亡 (apoptosis)。N6-Benzyladenosine 顯示出對(duì)弓形蟲腺苷激酶和膠質(zhì)瘤 (glioma) 的抑制作用。

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N6-Benzyladenosine Chemical Structure

N6-Benzyladenosine Chemical Structure

CAS No. : 4294-16-0

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10 mM * 1 mL in DMSO ￥550
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100 mg ￥500
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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

N6-Benzyladenosine is an adenosine receptor agonist, has a cytoactive activity. N6-Benzyladenosine arrests cell cycle at G0/G1 phase and induces cell apoptosis. N6-Benzyladenosine also exerts inhibitory effect on T. gondii adenosine kinase and glioma[1]-[5].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
B16 IC50
> 166.7 μM
Compound: BAPR
Antitumor activity against mouse B16 cells after 72 hrs by Calcein AM assay
Antitumor activity against mouse B16 cells after 72 hrs by Calcein AM assay
[PMID: 17418578]
Caco-2 GI50
7.4 μM
Compound: 19, BnA
Antitumor activity against human CaCo2 cells after 48 hrs by MTS assay
Antitumor activity against human CaCo2 cells after 48 hrs by MTS assay
[PMID: 18588281]
CCRF-CEM IC50
1.4 μM
Compound: BAPR
Antitumor activity against human CEM cells after 72 hrs by Calcein AM assay
Antitumor activity against human CEM cells after 72 hrs by Calcein AM assay
[PMID: 17418578]
G-361 IC50
> 166.7 μM
Compound: BAPR
Antitumor activity against human G361 cells after 72 hrs by Calcein AM assay
Antitumor activity against human G361 cells after 72 hrs by Calcein AM assay
[PMID: 17418578]
HL-60 IC50
0.94 μM
Compound: BAPR
Antitumor activity against human HL60 cells after 72 hrs by Calcein AM assay
Antitumor activity against human HL60 cells after 72 hrs by Calcein AM assay
[PMID: 17418578]
HOS IC50
> 166.7 μM
Compound: BAPR
Antitumor activity against human HOS cells after 72 hrs by Calcein AM assay
Antitumor activity against human HOS cells after 72 hrs by Calcein AM assay
[PMID: 17418578]
HT-29 GI50
22.3 μM
Compound: 19, BnA
Antitumor activity against human HT29 cells after 48 hrs by MTS assay
Antitumor activity against human HT29 cells after 48 hrs by MTS assay
[PMID: 18588281]
K562 GI50
2.92 μM
Compound: 19, BnA
Growth inhibition of 0.1 uM 1,4-dihydro-2-methyl-6-phenyl-4-(phenylethyl)-3,5-pyridine-dicarboxylic acid 3-ethyl-5-[(3-nitrophenyl) methyl] ester pretreated human K562 cells after 72 hrs by MTS assay
Growth inhibition of 0.1 uM 1,4-dihydro-2-methyl-6-phenyl-4-(phenylethyl)-3,5-pyridine-dicarboxylic acid 3-ethyl-5-[(3-nitrophenyl) methyl] ester pretreated human K562 cells after 72 hrs by MTS assay
[PMID: 18588281]
K562 GI50
2.92 μM
Compound: 19, BnA
Growth inhibition of 1 uM 1,4-dihydro-2-methyl-6-phenyl-4-(phenylethyl)-3,5-pyridine-dicarboxylic acid 3-ethyl-5-[(3-nitrophenyl) methyl] ester pretreated human K562 cells after 72 hrs by MTS assay
Growth inhibition of 1 uM 1,4-dihydro-2-methyl-6-phenyl-4-(phenylethyl)-3,5-pyridine-dicarboxylic acid 3-ethyl-5-[(3-nitrophenyl) methyl] ester pretreated human K562 cells after 72 hrs by MTS assay
[PMID: 18588281]
K562 GI50
3.91 μM
Compound: 19, BnA
Growth inhibition of 0.1 uM 1,4-dihydro-2-methyl-6-phenyl-4-(phenylethyl)-3,5-pyridine-dicarboxylic acid 3-ethyl-5-[(3-nitrophenyl) methyl] ester pretreated human K562 cells after 48 hrs by MTS assay
Growth inhibition of 0.1 uM 1,4-dihydro-2-methyl-6-phenyl-4-(phenylethyl)-3,5-pyridine-dicarboxylic acid 3-ethyl-5-[(3-nitrophenyl) methyl] ester pretreated human K562 cells after 48 hrs by MTS assay
[PMID: 18588281]
K562 GI50
4.17 μM
Compound: 19, BnA
Growth inhibition of 1 uM 1,4-dihydro-2-methyl-6-phenyl-4-(phenylethyl)-3,5-pyridine-dicarboxylic acid 3-ethyl-5-[(3-nitrophenyl) methyl] ester pretreated human K562 cells after 48 hrs by MTS assay
Growth inhibition of 1 uM 1,4-dihydro-2-methyl-6-phenyl-4-(phenylethyl)-3,5-pyridine-dicarboxylic acid 3-ethyl-5-[(3-nitrophenyl) methyl] ester pretreated human K562 cells after 48 hrs by MTS assay
[PMID: 18588281]
K562 GI50
4.6 μM
Compound: 19, BnA
Antitumor activity against human K562 cells after 48 hrs by MTS assay
Antitumor activity against human K562 cells after 48 hrs by MTS assay
[PMID: 18588281]
K562 IC50
5.5 μM
Compound: BAPR
Antitumor activity against human K562 cells after 72 hrs by Calcein AM assay
Antitumor activity against human K562 cells after 72 hrs by Calcein AM assay
[PMID: 17418578]
MCF7 GI50
61 μM
Compound: 19, BnA
Antitumor activity against human MCF7 cells after 48 hrs by MTS assay
Antitumor activity against human MCF7 cells after 48 hrs by MTS assay
[PMID: 18588281]
NIH3T3 IC50
39 μM
Compound: BAPR
Cytotoxicity against mouse NIH 3T3 cells after 72 hrs by Calcein AM assay
Cytotoxicity against mouse NIH 3T3 cells after 72 hrs by Calcein AM assay
[PMID: 17418578]
Platelet IC50
37.12 μM
Compound: 2d
Inhibition of collagen-induced human platelet aggregation after 3 mins by light transmission aggregometry
Inhibition of collagen-induced human platelet aggregation after 3 mins by light transmission aggregometry
[PMID: 25467153]
RD EC50
0.28 μM
Compound: 23
Antiviral activity against Enterovirus 71 infected in human RD cells assessed as cell viability after 3 days by MTS assay
Antiviral activity against Enterovirus 71 infected in human RD cells assessed as cell viability after 3 days by MTS assay
[PMID: 26854380]
體外研究
(In Vitro)

N6-benzyladenosine suppresses the clonogenic activity and the growth of different neoplastic cells[2].
N6-benzyladenosine results cell morphology alteration and actin cytoskeleton disorganization in T24 cell[2].
N6-benzyladenosine (10 μM; 24 h) is a potent inductor of apoptosis, and belongs to apoptotic systems with distinct caspase-3 and caspase-9 activation[3].
N6-benzyladenosine (0-100 μM; 24 h) induces chromatin condensation, formation of apoptotic bodies, and cleavage of DNA to nucleosomal fragments in a dose-dependent manner[3].
N6-benzyladenosine acts as a selective anti-toxoplasma agent with binding affinity to T. gondii adenosine kinase (apparent Km =179.8 μM), over human adenosine kinase[4].
N6-benzyladenosine (0-50 μM) shows weak inhibition against adenosine kinase deficient (TgAKS3) strains of Toxoplasma gondii[4].
N6-benzyladenosine (compound 2) (0.3-20 μM) exerts anti-glioma activity by interfering with the mevalonate pathway and inhibiting FPPS (Farnesyl pyrophosphate synthase) [5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[3]

Cell Line: HL-60
Concentration: 10 μM
Incubation Time: 24 hours
Result: Induced cell apoptosis by increasing caspase-3 (DEVDase) as well as caspase-9 (LEHDase) activity, indicating an apoptotic systems with distinct caspase-3/9 activation.

Apoptosis Analysis[5]

Cell Line: U87MG human glioma cell line.
Concentration: 0.3, 0.6, 1.2, 2.5, 5, 10, 20 μM
Incubation Time: 48 hours
Result: Inhibited glioma growth by interfering with the mevalonate pathway and inhibiting FPPS.
分子量

357.36

Formula

C17H19N5O4
CAS 號(hào)
性狀

固體

顏色

White to off-white

結(jié)構(gòu)分類
初始來(lái)源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 125 mg/mL (349.79 mM; 超聲助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開封的 DMSO)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.7983 mL 13.9915 mL 27.9830 mL
5 mM 0.5597 mL 2.7983 mL 5.5966 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料
參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7983 mL 13.9915 mL 27.9830 mL 69.9575 mL
5 mM 0.5597 mL 2.7983 mL 5.5966 mL 13.9915 mL
10 mM 0.2798 mL 1.3991 mL 2.7983 mL 6.9957 mL
15 mM 0.1866 mL 0.9328 mL 1.8655 mL 4.6638 mL
20 mM 0.1399 mL 0.6996 mL 1.3991 mL 3.4979 mL
25 mM 0.1119 mL 0.5597 mL 1.1193 mL 2.7983 mL
30 mM 0.0933 mL 0.4664 mL 0.9328 mL 2.3319 mL
40 mM 0.0700 mL 0.3498 mL 0.6996 mL 1.7489 mL
50 mM 0.0560 mL 0.2798 mL 0.5597 mL 1.3991 mL
60 mM 0.0466 mL 0.2332 mL 0.4664 mL 1.1660 mL
80 mM 0.0350 mL 0.1749 mL 0.3498 mL 0.8745 mL
100 mM 0.0280 mL 0.1399 mL 0.2798 mL 0.6996 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
N6-Benzyladenosine
目錄號(hào)：
HY-N7844
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