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  2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. Methyl oleanonate

Methyl oleanonate  (Synonyms: 3-Oxoolean-12-en-28-oic acid methyl ester)

目錄號: HY-N7624 純度: 99.81%
COA 產(chǎn)品使用指南 技術(shù)支持

Methyl oleanonate 是從 Pistacia lentiscus var. Chia 中分離得到的三萜類 PPARγ 激動劑。Methyl oleanonate 是齊墩果酸衍生物，具有抗癌作用。

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Methyl oleanonate Chemical Structure

Methyl oleanonate Chemical Structure

CAS No. : 1721-58-0

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥1000
In-stock
5 mg ￥2600
In-stock
10 mg ￥3900
In-stock
50 mg   詢價(jià)  
100 mg   詢價(jià)  

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查看 PPAR 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Methyl oleanonate is a natural triterpene PPARγ agonist isolated from the species of Pistacia lentiscus var. Chia[1]. Methyl oleanonate is a modified oleanolic acid derivative with anti-cancer effects[2].

IC50 & Target[1]

PPARγ

 

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
518A2 EC50
4.11 μM
Compound: 9
Cytotoxicity against human 518A2 cells assessed as cell survival after 96 hrs by SRB assay
Cytotoxicity against human 518A2 cells assessed as cell survival after 96 hrs by SRB assay
[PMID: 26177446]
HeLa IC50
> 100 μM
Compound: 3
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
[PMID: 24487188]
HT-29 IC50
> 100 μM
Compound: 3
Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
[PMID: 24487188]
HT-29 EC50
4.47 μM
Compound: 9
Cytotoxicity against human HT-29 cells assessed as cell survival after 96 hrs by SRB assay
Cytotoxicity against human HT-29 cells assessed as cell survival after 96 hrs by SRB assay
[PMID: 26177446]
J774.A1 IC50
33.5 μM
Compound: 4
Inhibition of LPS-induced NO production in mouse J774A1 cells compound preincubated for 1 hr before LPS treatment by Griess reaction
Inhibition of LPS-induced NO production in mouse J774A1 cells compound preincubated for 1 hr before LPS treatment by Griess reaction
[PMID: 25113933]
J774.A1 IC50
82.47 μM
Compound: 4
Cytotoxicity against mouse J774A1 cells assessed as cell viability by MTT assay relative to control
Cytotoxicity against mouse J774A1 cells assessed as cell viability by MTT assay relative to control
[PMID: 25113933]
MCF7 EC50
5.44 μM
Compound: 9
Cytotoxicity against human MCF7 cells assessed as cell survival after 96 hrs by SRB assay
Cytotoxicity against human MCF7 cells assessed as cell survival after 96 hrs by SRB assay
[PMID: 26177446]
MCF7 IC50
78.7 μM
Compound: 3
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 24487188]
MDA-MB-231 IC50
> 100 μM
Compound: 3
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
[PMID: 24487188]
MDA-MB-453 IC50
> 100 μM
Compound: 3
Cytotoxicity against human MDA-MB-453 cells after 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-453 cells after 48 hrs by MTT assay
[PMID: 24487188]
ME-180 IC50
> 100 μM
Compound: 3
Cytotoxicity against human ME180 cells after 48 hrs by MTT assay
Cytotoxicity against human ME180 cells after 48 hrs by MTT assay
[PMID: 24487188]
PC-3 IC50
> 100 μM
Compound: 3
Cytotoxicity against human PC3 cells after 48 hrs by MTT assay
Cytotoxicity against human PC3 cells after 48 hrs by MTT assay
[PMID: 24487188]
RAW264.7 IC50
31.7 μM
Compound: 4
Inhibition of LPS-induced NO production in mouse RAW264.7 cells compound preincubated for 1 hr before LPS treatment by Griess reaction
Inhibition of LPS-induced NO production in mouse RAW264.7 cells compound preincubated for 1 hr before LPS treatment by Griess reaction
[PMID: 25113933]
RAW264.7 IC50
79.3 μM
Compound: 4
Cytotoxicity mouse RAW264.7 cells assessed as cell viability by MTT assay relative to control
Cytotoxicity mouse RAW264.7 cells assessed as cell viability by MTT assay relative to control
[PMID: 25113933]
分子量

468.71

Formula

C31H48O3
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

3-Keto-齊墩果酸-28-甲酯
結(jié)構(gòu)分類
初始來源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 2.5 mg/mL (5.33 mM; 超聲助溶 (<60°C); 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.1335 mL 10.6676 mL 21.3352 mL
5 mM 0.4267 mL 2.1335 mL 4.2670 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請?jiān)?個月內(nèi)使用，-20°C儲存時，請?jiān)?個月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計(jì)算器
請輸入動物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實(shí)驗(yàn)過程有損耗，建議您多配一只動物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.81%

參考文獻(xiàn)

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請?jiān)?個月內(nèi)使用，-20°C儲存時，請?jiān)?個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1335 mL 10.6676 mL 21.3352 mL 53.3379 mL
5 mM 0.4267 mL 2.1335 mL 4.2670 mL 10.6676 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Methyl oleanonate
目錄號：
HY-N7624
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